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lysyl oxidase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

4015

PubChem

4015

Alliance of Genome Resources

HGNC:6664

Annotation

Keyword

Aortic aneurysm
Copper
Disease variant
Disulfide bond
Glycoprotein
LTQ
Metal-binding
Oxidoreductase
Proteomics identification
Reference proteome
Secreted
Signal
Sulfation
TPQ

Proteins

Displaying **all 4** entries
UniProt	Protein Name
D0PNI2
B0AZT2
B7ZAJ4
P28300	Lysyl oxidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
regulation of platelet-derived growth factor receptor-beta signaling pathway	IEA
regulation of striated muscle tissue development	IEA
bone mineralization	IEA
regulation of protein phosphorylation
heart development	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

macromolecule modification [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein oxidation [inference]

peptidyl-lysine oxidation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine oxidation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway [inference]

platelet-derived growth factor receptor-beta signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

muscle cell development

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

connective tissue development

cell development [inference]

muscle cell development

animal organ development [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cell development [inference]

muscle cell development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to steroid hormone

response to organic cyclic compound [inference]

response to steroid hormone

response to lipid [inference]

response to steroid hormone

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

response to chemokine [inference]

cellular response to chemokine

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of muscle organ development [inference]

regulation of striated muscle tissue development

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development

regulation of multicellular organismal development [inference]

regulation of bone development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway [inference]

platelet-derived growth factor receptor-beta signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of bone development

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of megakaryocyte differentiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	IBA
extracellular region	ISS TAS
collagen trimer	IEA
extracellular space	IBA IDA	31152061

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	19570982 19855011 21690299 22919265 25118846 26601954 27339457 30082873
protein-lysine 6-oxidase activity	IBA IDA ISS	31152061
copper ion binding	IEA
collagen binding	IDA	31152061
small molecule binding	IPI	30082873

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [inference]

protein-lysine 6-oxidase activity

catalytic activity, acting on a protein [inference]

protein-lysine 6-oxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

protein-containing complex binding [inference]

collagen binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Lysyl oxidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
collagen fibril organization
copper ion binding
metal ion binding
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
oxidoreductase activity

Displaying **all 3** entries
InterPro
Lysyl oxidase, conserved site
Lysyl oxidase
SRCR domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:13359	Ehlers-Danlos syndrome	Alliance of Genome Resources
DOID:14004	thoracic aortic aneurysm	Alliance of Genome Resources
DOID:1838	Menkes disease	Alliance of Genome Resources
DOID:1928	Williams-Beuren syndrome	Alliance of Genome Resources
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:2349	arteriosclerosis	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:4247	coronary restenosis	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16948		MGI:96817	MOUSE24242
Rattus norvegicus	24914		RGD:3015	RATNO13302
Bos taurus	280841			BOVIN33103
Danio rerio	404621		ZFIN:ZDB-GENE-040426-2398
Pan troglodytes	471614	9598_0:00181b		PANTR35994
Canis lupus familiaris	481478			CANLF02038
Macaca mulatta	699997			MACMU39072
Xenopus laevis	734204		Xenbase:XB-GENE-491969
Xenopus tropicalis	780067		Xenbase:XB-GENE-491965
Monodelphis domestica	100027065			MONDO29564

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements