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Presenilin

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

40260

PubChem

40260

Alliance of Genome Resources

FB:FBgn0284421

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Notch signaling pathway
Protease
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
O02194	dPS
M9PG70
B7Z090
M9PFS2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
regulation of heart rate	IMP	21524270
proteolysis	IDA	15611340
membrane protein ectodomain proteolysis	IDA	20421416
membrane protein ectodomain proteolysis	IBA
apoptotic process	IMP	10491396

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

membrane protein intracellular domain proteolysis [inference]

Notch receptor processing, ligand-dependent

Notch receptor processing

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process [inference]

amyloid-beta formation

protein maturation [inference]

protein processing

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

memory [inference]

short-term memory

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

wing disc pattern formation [inference]

wing disc dorsal/ventral pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

memory [inference]

short-term memory

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

copper ion transport [inference]

copper ion import

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate

regulation of biological quality [inference]

regulation of heart rate

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Golgi membrane
late endosome	IDA	20421416
endoplasmic reticulum membrane
plasma membrane	IDA	10662508
membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

gamma-secretase complex

catalytic complex [inference]

gamma-secretase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	IDA	15611340 28495961
endopeptidase activity	IMP	15105831 20421416
endopeptidase activity	IBA
protein binding	IPI	23609534
aspartic endopeptidase activity, intramembrane cleaving	IDA	11030342

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PRESENILIN

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
Notch receptor processing
amyloid precursor protein catabolic process
amyloid-beta metabolic process
aspartic endopeptidase activity, intramembrane cleaving
aspartic-type endopeptidase activity
calcium ion transport
hydrolase activity
membrane protein ectodomain proteolysis
proteolysis

Displaying **all 3** entries
InterPro
Peptidase A22A, presenilin
Presenilin, C-terminal
Presenilin/signal peptide peptidase

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
basal plasma membrane	PMID:10662508
recycling endosome	PMID:20421416
plasma membrane	PMID:10662508
apical plasma membrane	PMID:10662508 PMID:11781576
membrane	FB:FBrf0231198
late endosome	PMID:20421416
gamma-secretase complex	PMID:12660785

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060894	early-onset Parkinson's disease	Alliance of Genome Resources
DOID:0110042	Alzheimer's disease 3	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources