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LDL receptor related protein 1

Summary

Gene Symbol

LRP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4035

PubChem

4035

Alliance of Genome Resources

HGNC:6692

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Cell membrane
Coated pit
Cytoskeleton
Developmental protein
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Endocytosis
Glycoprotein
Golgi apparatus
Host-virus interaction
Lipoprotein
Metal-binding
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q59FG2
Q07954	Alpha-2-macroglobulin receptor Apolipoprotein E receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
regulation of extracellular matrix disassembly	TAS	14645246
amyloid-beta clearance	NAS TAS	19098903 20199584
negative regulation of Wnt signaling pathway	ISS
positive regulation of protein localization to plasma membrane	IGI	23386614
cellular response to amyloid-beta	ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

primary metabolic process [inference]

lipid metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

glial cell activation [inference]

astrocyte activation [inference]

astrocyte activation involved in immune response

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

apoptotic cell clearance

transcytosis

amyloid-beta clearance by transcytosis

cellular metabolic process [inference]

cellular catabolic process [inference]

amyloid-beta clearance by cellular catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

glial cell activation [inference]

astrocyte activation [inference]

astrocyte activation involved in immune response

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

transcytosis

amyloid-beta clearance by transcytosis

amyloid-beta clearance

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

aorta morphogenesis

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

response to peptide [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to peptide [inference]

cellular response to amyloid-beta

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

apoptotic cell clearance

transcytosis

amyloid-beta clearance by transcytosis

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

organic substance transport [inference]

protein transport [inference]

lipoprotein transport

nitrogen compound transport [inference]

protein transport [inference]

lipoprotein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

receptor internalization

phagocytosis

apoptotic cell clearance

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of transport [inference]

positive regulation of lipid transport

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of transcytosis [inference]

positive regulation of transcytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of transcytosis

positive regulation of transport [inference]

positive regulation of lipid transport

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of multicellular organismal process [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid transport

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of platelet-derived growth factor receptor-beta signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of transcytosis

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of SMAD protein signal transduction

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of transcytosis [inference]

positive regulation of transcytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

regulation of amyloid-beta clearance [inference]

positive regulation of amyloid-beta clearance

regulation of transcytosis [inference]

positive regulation of transcytosis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of protein binding

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of metallopeptidase activity [inference]

negative regulation of metallopeptidase activity

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

regulation of phospholipase A2 activity

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

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GO Term	Evidence Code	PMID
membrane	NAS	23386614
early endosome	IDA	26005850
Golgi apparatus	IEA
focal adhesion	HDA	21423176
receptor complex	IDA	23382219

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

membrane protein complex [inference]

plasma membrane protein complex

cellular anatomical entity [inference]

microtubule organizing center

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endocytic vesicle membrane

plasma membrane region [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	10772929 15182176 17326667 17360663 20030366 20472562 21054788 21968187 24284412 26005850 28514442 29547901 32814053 33961781 8626514
heparan sulfate proteoglycan binding	TAS	21289173
scavenger receptor activity	TAS	11240025
apolipoprotein receptor activity	TAS	21289173
protein-containing complex binding	IDA	8626514

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding

clathrin binding [inference]

clathrin heavy chain binding

apolipoprotein binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

carbohydrate derivative binding [inference]

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

heparan sulfate proteoglycan binding

cargo receptor activity

lipoprotein particle receptor activity [inference]

low-density lipoprotein particle receptor activity

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Low-density lipoprotein receptor-related protein

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 2** entries
InterPro
LDLR class B repeat
Six-bladed beta-propeller, TolB-like

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0060327	omphalocele	Alliance of Genome Resources
DOID:0080751	keratosis pilaris atrophicans	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11044	gastroschisis	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:3827	congenital diaphragmatic hernia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:8634	prostate carcinoma in situ	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	16971		MGI:96828	MOUSE01086
Drosophila melanogaster	35799		FB:FBgn0053087
Rattus norvegicus	299858		RGD:1307535	RATNO38235
Pan troglodytes	452006	9598_0:0033fd		PANTR05514
Canis lupus familiaris	481124			CANLF01335
Xenopus laevis	496382		Xenbase:XB-GENE-865314
Bos taurus	533894			BOVIN29580
Danio rerio	563149		ZFIN:ZDB-GENE-030131-7889	DANRE02086
Danio rerio	565797		ZFIN:ZDB-GENE-030131-7126	DANRE23964
Macaca mulatta	710965			MACMU05416

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements