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LDL receptor related protein 2

Summary

Gene Symbol

LRP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4036

PubChem

4036

Alliance of Genome Resources

HGNC:6694

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Cell projection
Coated pit
Deafness
Disease variant
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Hearing
Metal-binding
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Repeat
SH3-binding
Signal
Transmembrane helix
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P98164	Glycoprotein 330 Megalin
Q7Z5C1
Q7Z5C0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
amyloid-beta clearance	ISS
sensory perception of sound	ISS
phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI	27241555
cobalamin transport	TAS
endocytosis	TAS	7768901

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

vitamin D metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin D metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

vitamin D metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

vitamin D metabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process

vitamin D metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cell population proliferation

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

transcytosis

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

transmembrane transport [inference]

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import across plasma membrane [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

pattern specification process [inference]

regionalization [inference]

specification of animal organ identity [inference]

heart field specification [inference]

secondary heart field specification

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

coronary vasculature morphogenesis [inference]

coronary artery morphogenesis

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis [inference]

ventricular compact myocardium morphogenesis

cardiac septum morphogenesis [inference]

outflow tract septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

cardiac septum development [inference]

ventricular septum development

forebrain development

animal organ development [inference]

kidney development

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

cranial skeletal system development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to leptin

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to leptin

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

vascular transport [inference]

transport across blood-brain barrier

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

transcytosis

vitamin transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

cobalamin transport

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

transmembrane transport [inference]

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import across plasma membrane [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

organic substance transport [inference]

protein transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

cobalamin transport

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

nitrogen compound transport [inference]

amide transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import into cell [inference]

endocytosis

receptor-mediated endocytosis

folate import across plasma membrane

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of protein catabolic process in the vacuole [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of protein catabolic process in the vacuole [inference]

positive regulation of lysosomal protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of neural precursor cell proliferation [inference]

regulation of oligodendrocyte progenitor proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

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GO Term	Evidence Code	PMID
external side of plasma membrane	ISS
Golgi apparatus	IEA
apical plasma membrane	IBA IDA ISS	23825075
receptor complex	IBA IDA ISS	23382219
plasma membrane	IBA TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	23825075 28514442 33961781 9773776
insulin-like growth factor I binding	ISS
protein transporter activity	ISS
SH3 domain binding	IEA
hormone binding	IBA

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding

growth factor binding [inference]

insulin-like growth factor binding [inference]

insulin-like growth factor I binding

protein domain specific binding [inference]

SH3 domain binding

protein-folding chaperone binding

hormone binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

cargo receptor activity

lipoprotein particle receptor activity [inference]

low-density lipoprotein particle receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

low-density lipoprotein receptor-related protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium ion binding
hormone binding
receptor-mediated endocytosis

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InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
NOTCH1 EGF-like calcium-binding domain

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0090144	Donnai-Barrow syndrome	Alliance of Genome Resources
DOID:1062	Fanconi syndrome	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:11829	degenerative myopia	Alliance of Genome Resources
DOID:11830	myopia	Alliance of Genome Resources
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:2527	nephrosis	Alliance of Genome Resources
DOID:7188	autoimmune thyroiditis	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	14725		MGI:95794	MOUSE32037
Rattus norvegicus	29216		RGD:68407
Caenorhabditis elegans	172520		WB:WBGene00003071
Pan troglodytes	459713	9598_0:000d19		PANTR29055
Danio rerio	568184		ZFIN:ZDB-GENE-050119-2
Drosophila melanogaster	8674055		FB:FBgn0261260
Monodelphis domestica	100024150			MONDO23216
Equus caballus	100062836			HORSE13943
Ornithorhynchus anatinus	100083379			ORNAN26801
Xenopus laevis	100126618		Xenbase:XB-GENE-6253809

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements