GlyCosmos Portal

Annotation

Keyword

Alternative promoter usage
Alternative splicing
Fatty acid metabolism
Heme
Microsome
Monooxygenase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q08477	20-hydroxyeicosatetraenoic acid synthase CYPIVF3 Cytochrome P450-LTB-omega Docosahexaenoic acid omega-hydroxylase CYP4F3 Leukotriene-B(4) 20-monooxygenase 2 Leukotriene-B(4) omega-hydroxylase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
leukotriene B4 catabolic process	IEA
arachidonic acid metabolic process	IEA
icosanoid metabolic process
leukotriene metabolic process

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative catabolic process [inference]

icosanoid catabolic process [inference]

leukotriene B4 catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

organic hydroxy compound catabolic process [inference]

leukotriene B4 catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process

leukotriene metabolic process

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative catabolic process [inference]

icosanoid catabolic process [inference]

leukotriene B4 catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative metabolic process [inference]

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative catabolic process [inference]

icosanoid catabolic process [inference]

leukotriene B4 catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process

leukotriene metabolic process

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process

leukotriene metabolic process

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative catabolic process [inference]

icosanoid catabolic process [inference]

leukotriene B4 catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative metabolic process [inference]

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative catabolic process [inference]

icosanoid catabolic process [inference]

leukotriene B4 catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid derivative catabolic process [inference]

icosanoid catabolic process [inference]

leukotriene B4 catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

organic hydroxy compound catabolic process [inference]

leukotriene B4 catabolic process

organic hydroxy compound metabolic process [inference]

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

organic hydroxy compound catabolic process [inference]

leukotriene B4 catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process

leukotriene metabolic process

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

leukotriene catabolic process [inference]

leukotriene B4 catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

leukotriene B4 metabolic process [inference]

leukotriene B4 catabolic process

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

long-chain fatty acid catabolic process [inference]

leukotriene B4 catabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
leukotriene-B4 20-monooxygenase activity
monooxygenase activity
iron ion binding	IEA
aromatase activity	IEA
20-hydroxy-leukotriene B4 omega oxidase activity

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

20-hydroxy-leukotriene B4 omega oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000186529

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K17726

Name

phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase [EC:1.14.14.78 1.14.14.79 1.14.14.94]

References

Rhea

RHEA:40155

O₂ + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate

H₂O + H⁺ + 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate

Enzyme

1.14.14.79

PMID

RHEA:22176

O₂ + leukotriene B₄

H₂O + H⁺ + 20-hydroxy-leukotriene B₄

Enzyme

1.14.14.94

PMID

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **211** in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050540	Charcot-Marie-Tooth disease type 3	DisGeNET
DOID:0050548	hereditary sensory neuropathy	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0050811	congenital adrenal hyperplasia	DisGeNET DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060185	Clostridium difficile colitis	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060306	Meier-Gorlin syndrome	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002363
Gene Name: cytochrome P450, family 4, subfamily F, polypeptide 3

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ciona intestinalis	100186171		CIOIN09049
Ciona intestinalis	100187185		CIOIN08694
Lepisosteus oculatus	102682840		LEPOC14813
Danio rerio	100037390	ZFIN:ZDB-GENE-070410-108
Electrophorus electricus	113590686		ELEEL45147
Salmo trutta	115152719		SALTR07004
Salmo trutta	115152720		SALTR07004
Gadus morhua	115542292		GADMO45012
Xiphophorus maculatus	102221417		XIPMA22648
Oreochromis niloticus	100711688		ORENI44823

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements