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leukotriene C4 synthase

Summary

Gene Symbol

LTC4S

Aliases

MGC33147

Organism

Homo sapiens (human)

External Links

NCBI Gene

4056

HGNC

6719

KEGG Gene ID

hsa:4056

PubChem

4056

Alliance of Genome Resources

HGNC:6719

JoGo

LTC4S

TogoVar

LTC4S

Annotation

Keyword

3D-structure
Direct protein sequencing
Endoplasmic reticulum
Leukotriene biosynthesis
Lipid biosynthesis
Lyase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16873	Glutathione S-transferase LTC4 Leukotriene-C(4) synthase Leukotriene-C4 synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
leukotriene metabolic process	IDA	8706658 9153254
leukotriene biosynthetic process	IBA
long-chain fatty acid biosynthetic process	IDA	27791009
cellular oxidant detoxification	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

leukotriene metabolic process

leukotriene biosynthetic process

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process [inference]

leukotriene biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular detoxification [inference]

cellular oxidant detoxification

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nuclear envelope	TAS
nuclear envelope	IDA	19233132 7599836
nuclear envelope	IBA
nuclear outer membrane	IDA	12023288
endoplasmic reticulum	IDA	19233132

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

nuclear membrane

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

Displaying entries **1 - 5** of 8 in total

1

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GO Term	Evidence Code	PMID
glutathione transferase activity	IBA
leukotriene-C4 synthase activity	IDA	8706658 9153254
leukotriene-C4 synthase activity	IBA
glutathione peroxidase activity	IBA
protein binding	IPI	19233132 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

glutathione peroxidase activity

transferase activity [inference]

transferase activity, transferring alkyl or aryl (other than methyl) groups [inference]

glutathione transferase activity

lyase activity [inference]

carbon-sulfur lyase activity [inference]

leukotriene-C4 synthase activity

binding [inference]

protein binding

identical protein binding

lipid binding

antioxidant activity [inference]

peroxidase activity [inference]

glutathione peroxidase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

leukotriene c4 synthase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
glutathione transferase activity
leukotriene biosynthetic process
leukotriene metabolic process
leukotriene-C4 synthase activity
lyase activity

Displaying **all 3** entries
InterPro
5-lipoxygenase-activating protein
Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein

KEGG BRITE Database

Orthology

K00807

Name

leukotriene-C4 synthase [EC:4.4.1.20]

References

8626689

Rhea

RHEA:17617

leukotriene C₄

leukotriene A₄ + glutathione

Enzyme

4.4.1.20

PMID

Disease

The Human Phenotype Ontology

Displaying **all 6** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0001252	Hypotonia
HP:0001263	Global developmental delay
HP:0001522	Death in infancy
HP:0001531	Failure to thrive in infancy