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NMDA receptor 1

Summary

Gene Symbol

Nmdar1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

40665

PubChem

40665

Alliance of Genome Resources

FB:FBgn0010399

Annotation

Keyword

Calcium
Cell membrane
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Magnesium
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q24418

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
sensory perception of touch	IMP	23103192
phototaxis	IDA	20039946
medium-term memory	IMP	17982450
calcium ion homeostasis	IMP	15823532
behavioral response to ethanol	IMP	23145041

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of touch

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

olfactory learning

memory [inference]

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

olfactory learning

memory [inference]

chemosensory behavior [inference]

olfactory behavior [inference]

olfactory learning

adult behavior [inference]

behavioral response to ethanol

locomotion [inference]

taxis [inference]

energy taxis [inference]

phototaxis

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

phototaxis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
membrane	IDA IEA	15823532
postsynaptic membrane	IDA	15823532
postsynaptic density
NMDA selective glutamate receptor complex	IBA IDA	15823532
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

NMDA selective glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

NMDA selective glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

NMDA selective glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

NMDA selective glutamate receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ligand-gated monoatomic ion channel activity	IBA IEA
NMDA glutamate receptor activity	IBA IDA ISS	10798390 15823532
signaling receptor activity	IBA IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

NMDA glutamate receptor activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

NMDA glutamate receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

NMDA glutamate receptor activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

NMDA glutamate receptor activity

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

amide transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

salt transmembrane transporter activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

glutamate receptor activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity [inference]

NMDA glutamate receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ligand-gated monoatomic ion channel activity
monoatomic ion transport

Displaying **all 2** entries
InterPro
Periplasmic binding protein-like I
Receptor, ligand binding region

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
membrane	FB:FBrf0231198 PMID:15823532
postsynaptic membrane	PMID:15823532
NMDA selective glutamate receptor complex	PMID:15823532

Disease

Disease Ontology

Displaying entries **1 - 10** of 16 in total

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DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0070038	autosomal dominant intellectual developmental disorder 8	Alliance of Genome Resources
DOID:0070387	developmental and epileptic encephalopathy 101	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11206	opioid abuse	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:1561	cognitive disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	2902		HGNC:4584
Mus musculus	14810		MGI:95819
Rattus norvegicus	24408		RGD:2736
Caenorhabditis elegans	173929		WB:WBGene00003774
Danio rerio	767745		ZFIN:ZDB-GENE-051202-1
Xenopus tropicalis	780048		Xenbase:XB-GENE-494200
Drosophila pseudoobscura	4802433	7237_0:0019b6
Drosophila ananassae	6500487	7217_1:00064f
Drosophila yakuba	6535418	7245_1:00341b
Drosophila erecta	6552207	7220_1:000b8e

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements