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Spindle assembly abnormal 4

Summary

Gene Symbol

Sas-4

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

40859

PubChem

40859

Alliance of Genome Resources

FB:FBgn0011020

Annotation

Keyword

3D-structure
Coiled coil
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VI72

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
centrosome cycle	IMP	16814722 18196975 19293139 21694707
male meiotic nuclear division	IMP	18196975
centriole elongation	IBA
asymmetric cell division	IDA IMP	16814722 20194641
centrosome separation	IMP	24687279

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule polymerization

microtubule organizing center organization [inference]

centrosome cycle

centriole assembly [inference]

centriole replication

cell cycle [inference]

mitotic cell cycle [inference]

cell cycle comprising mitosis without cytokinesis [inference]

syncytial blastoderm mitotic cell cycle

mitotic cell cycle, embryonic [inference]

syncytial blastoderm mitotic cell cycle

cell cycle process [inference]

meiotic cell cycle process [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

cellular process involved in reproduction in multicellular organism [inference]

male meiotic nuclear division

cell division [inference]

asymmetric cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome [inference]

protein localization to pericentriolar material

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule polymerization

cilium organization [inference]

cilium assembly

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

organelle assembly [inference]

cilium assembly

non-membrane-bounded organelle assembly [inference]

centriole assembly [inference]

centriole replication

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

organelle assembly [inference]

cilium assembly

non-membrane-bounded organelle assembly [inference]

centriole assembly [inference]

centriole replication

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

microtubule organizing center organization [inference]

centrosome cycle

centriole assembly [inference]

centriole replication

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

microtubule polymerization

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

male meiotic nuclear division

meiotic cell cycle process [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

locomotion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome [inference]

protein localization to pericentriolar material

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cytoskeleton [inference]

protein localization to microtubule cytoskeleton [inference]

protein localization to microtubule organizing center [inference]

protein localization to centrosome [inference]

protein localization to pericentriolar material

Displaying **all 4** entries
GO Term	Evidence Code	PMID
pericentriolar material	IDA	21694707
centriole	IBA IDA	16814722 17412918 17475495 18798690 19293139 21145506 27764551
centrosome	IBA
cytoplasm	HDA	26896675

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

Displaying **all 2** entries
GO Term	Evidence Code	PMID
tubulin binding	IBA
molecular adaptor activity	IPI	21694707

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

tubulin binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
centriole elongation
tubulin binding

Displaying **all 3** entries
InterPro
Centromere protein J, C-terminal domain
T-complex protein 10 family
T-complex protein 10, C-terminal domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
pericentriolar material	PMID:21694707
cytoplasm	PMID:26896675
centriole	PMID:16814722 PMID:17412918 PMID:17475495 PMID:18798690 PMID:19293139 PMID:21145506 PMID:27764551

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050569	Seckel syndrome	Alliance of Genome Resources
DOID:0070010	Seckel syndrome 4	Alliance of Genome Resources
DOID:0070290	primary autosomal recessive microcephaly 6	Alliance of Genome Resources
DOID:0070296	primary autosomal recessive microcephaly	Alliance of Genome Resources
DOID:10907	microcephaly	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	21461		MGI:98541
Mus musculus	21462		MGI:98542
Homo sapiens	55835		HGNC:17272
Mus musculus	219103		MGI:2684927
Rattus norvegicus	305909		RGD:1310464
Rattus norvegicus	308169		RGD:1307454
Danio rerio	568957		ZFIN:ZDB-GENE-030131-6323
Drosophila ananassae	6500441	7217_1:0004d0
Drosophila yakuba	6536080	7245_1:0031f4
Drosophila erecta	6553194	7220_1:00079b

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Annotation

OrthoDB (Group)

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Acknowledgements