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ATPase H+ transporting accessory protein 2

Summary

Gene Symbol

ATP6AP2

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

41104

KEGG Gene ID

dme:Dmel_CG8444

PubChem

41104

Alliance of Genome Resources

FB:FBgn0037671

Annotation

Keyword

Cell membrane
Cleavage on pair of basic residues
Endoplasmic reticulum
Golgi apparatus
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9VHG4	Renin homolog receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
phototaxis	IMP	26376863
positive regulation of Wnt signaling pathway	IBA
establishment of imaginal disc-derived wing hair orientation	IMP	23292348
endosomal transport	IMP	23292348
vacuolar proton-transporting V-type ATPase complex assembly	IGI	29995586

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

vesicle-mediated transport [inference]

endosomal transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization involved in establishment of planar polarity

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

proton-transporting two-sector ATPase complex assembly [inference]

proton-transporting V-type ATPase complex assembly [inference]

vacuolar proton-transporting V-type ATPase complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

non-sensory hair organization [inference]

imaginal disc-derived wing hair organization

cell junction organization [inference]

synapse organization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

proton-transporting two-sector ATPase complex assembly [inference]

proton-transporting V-type ATPase complex assembly [inference]

vacuolar proton-transporting V-type ATPase complex assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

behavior [inference]

learning or memory [inference]

memory [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

post-embryonic animal morphogenesis [inference]

establishment of imaginal disc-derived wing hair orientation

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

compound eye development

locomotion [inference]

taxis [inference]

energy taxis [inference]

phototaxis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

phototaxis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization involved in establishment of planar polarity

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

vesicle-mediated transport [inference]

endosomal transport

intracellular transport [inference]

endosomal transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization involved in establishment of planar polarity

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
membrane	IEA
endoplasmic reticulum membrane	IDA	29995586
plasma membrane	IDA	20579883
vacuolar proton-transporting V-type ATPase complex	IMP ISS	29127204 29995586

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex [inference]

vacuolar proton-transporting V-type ATPase complex

catalytic complex [inference]

ATPase complex [inference]

proton-transporting two-sector ATPase complex [inference]

proton-transporting V-type ATPase complex [inference]

vacuolar proton-transporting V-type ATPase complex

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

apical part of cell

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
frizzled binding	IDA	20579883
signaling receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

frizzled binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATPase H+ transporting accessory protein 2

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Renin receptor-like

KEGG BRITE Database

Orthology

K19514

Name

renin receptor

References

25374826

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
apical part of cell	PMID:23292348
endoplasmic reticulum membrane	PMID:29995586
cell surface	PMID:23292348
membrane	FB:FBrf0231198
plasma membrane	PMID:20579883
Golgi membrane	PMID:29995586

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050571	congenital disorder of glycosylation type II	Alliance of Genome Resources
DOID:0060309	syndromic X-linked intellectual disability	Alliance of Genome Resources
DOID:0060806	syndromic X-linked intellectual disability Hedera type	Alliance of Genome Resources
DOID:0112105	X-linked parkinsonism-spasticity syndrome	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:5212	congenital disorder of glycosylation	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	10159		HGNC:18305
Mus musculus	70495		MGI:1917745
Caenorhabditis elegans	174109		WB:WBGene00020500
Rattus norvegicus	302526		RGD:1561269
Danio rerio	406296		ZFIN:ZDB-GENE-040426-1960
Xenopus tropicalis	496778		Xenbase:XB-GENE-964301
Drosophila pseudoobscura	4800355	7237_1:000239
Drosophila ananassae	6499383	7217_1:00029f
Drosophila yakuba	6536332	7245_1:0030f7
Drosophila erecta	6552497	7220_1:000975