steroid sulfatase

Summary
Gene Symbol
  • STS
Aliases
  • ARSC
  • arylsulfatase C
  • steryl-sulfatase
Organism
Homo sapiens (human)
External Links
NCBI Gene
412
HGNC
11425
KEGG Gene ID
hsa:412
PubChem
412
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Calcium
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Endoplasmic reticulum
  • Glycoprotein
  • Hydrolase
  • Ichthyosis
  • Metal-binding
  • Pregnancy
  • Proteomics identification
  • Reference proteome
  • Signal
  • Steroid metabolism
  • Transmembrane helix
Proteins
Displaying all 4 entries
UniProt Protein Name
A6PYA4
P08842
  • Arylsulfatase C
  • Estrone sulfatase
  • Steroid sulfatase
  • Steryl-sulfate sulfohydrolase
A0A590UJL0
Q0W975
Gene Ontology (GO)
Displaying all 3 entries
GO Term Evidence Code PMID
steroid catabolic process
epidermis development
female pregnancy
Human Protein Atlas
ENSG00000101846

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K01131
Name
steryl-sulfatase [EC:3.1.6.2]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 476 in total
DO ID Disease Name Source
DOID:0014667 disease of metabolism
DOID:0040084 Streptococcus pneumonia
DOID:0040085 bacterial sepsis
DOID:0050175 tick-borne encephalitis
DOID:0050387 nonpapillary renal cell carcinoma
DOID:0050441 mucosulfatidosis
DOID:0050452 mevalonic aciduria
DOID:0050453 lissencephaly
DOID:0050457 Sertoli cell-only syndrome
DOID:0050569 Seckel syndrome
The Human Phenotype Ontology
Displaying entries 1 - 10 of 34 in total
HPO ID HPO Term
HP:0000028 Cryptorchidism
HP:0000083 Renal insufficiency
HP:0000122 Unilateral renal agenesis
HP:0000135 Hypogonadism
HP:0000717 Autism
HP:0000958 Dry skin
HP:0000962 Hyperkeratosis
HP:0000966 Hypohidrosis
HP:0000982 Palmoplantar keratoderma
HP:0001249 Intellectual disability
Displaying all 3 entries
Disease ID Disease Name
ORPHA:461
  • recessive X-linked ichthyosis
OMIM:308100
  • recessive X-linked ichthyosis
ORPHA:281090
  • recessive X-linked ichthyosis
  • syndromic recessive X-linked ichthyosis
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP006680
Gene Name
steroid sulfatase (microsomal), isozyme S

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Acknowledgements

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Last updated: August 19, 2024