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MIRAGE
mannosidase alpha class 2A member 2

Summary
Gene Symbol
  • MAN2A2
Aliases
  • HsT19662
  • MANA2X
Organism
Homo sapiens (human)
NCBI Gene
4122
HGNC
6825
KEGG Gene ID
hsa:4122
PubChem
4122
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Disulfide bond
  • Glycoprotein
  • Glycosidase
  • Golgi apparatus
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
  • Zinc
Proteins
Displaying 1 entry
UniProt Protein Name
P49641
  • Alpha-mannosidase IIx
  • Mannosidase alpha class 2A member 2
  • Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 3 entries
GO Term Evidence Code PMID
mannose metabolic process
protein glycosylation
N-glycan processing
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
alpha mannosidase
Functional Category
  • G: Carbohydrate transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
Displaying all 5 entries
Gene Ontology
alpha-mannosidase activity
catalytic activity
hydrolase activity, acting on glycosyl bonds
mannose metabolic process
metal ion binding
Displaying all 8 entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase 38, N-terminal domain superfamily
Glycoside hydrolase families 57/38, central domain superfamily
Glycoside hydrolase family 38, N-terminal domain
Glycoside hydrolase family 38, central domain superfamily
Glycoside hydrolase family 38, central domain
Glycoside hydrolase/deacetylase, beta/alpha-barrel
Glycosyl hydrolase family 38, C-terminal
KEGG BRITE Database
Orthology
K01231
Name
alpha-mannosidase II [EC:3.2.1.114]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R05984
Rhea

RHEA:56052

H2O
α-D-mannopyranose
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 93 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
4122 Xenbase:XB-GENE-981388
4124 FB:FBgn0011740
17158 FB:FBgn0011740
25478 FB:FBgn0011740
41126 Xenbase:XB-GENE-981388
140481 Xenbase:XB-GENE-981388 MOUSE54363
179632 Xenbase:XB-GENE-981388
308757 RATNO17642
488745 CANLF12076
715720 MACMU42079
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025