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microtubule affinity regulating kinase 3

Summary

Gene Symbol

MARK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4140

PubChem

4140

Alliance of Genome Resources

HGNC:6897

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cell projection
Cytoplasm
Disease variant
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying **all 7** entries
UniProt	Protein Name
A0A7I2V3B9
A0A7I2V2E3
Q86U11
H0YNV4
A0A7I2YQF7
P27448	C-TAK1 Cdc25C-associated protein kinase 1 ELKL motif kinase 2 Protein kinase STK10 Ser/Thr protein kinase PAR-1 Serine/threonine-protein kinase p78
A0A7I2V639

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
negative regulation of hippo signaling	IDA	28087714
peptidyl-serine phosphorylation	IDA	9543386
protein phosphorylation	IMP	23666762
negative regulation of protein localization to nucleus	IDA	16822840
positive regulation of protein binding	IDA	9543386

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine autophosphorylation

protein autophosphorylation [inference]

peptidyl-serine autophosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

negative regulation of hippo signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of hippo signaling

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to nucleus [inference]

negative regulation of protein localization to nucleus

negative regulation of protein localization [inference]

negative regulation of protein localization to nucleus

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA	21145462
dendrite	IDA	23666762
cytosol	TAS
cytoplasm	IBA IDA NAS	23666762 9543386
extracellular exosome	HDA	18570454

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12556533 12941695 14676191 15161933 15778465 16169070 16189514 16306228 16959763 16980613 17979178 22046132 23666762 24255178 25852190 28087714 28514442 32707033 33961781 35271311 36931259 37207277 9543386
protein serine kinase activity	IEA
protein serine/threonine kinase activity	IBA IDA NAS	12941695 16822840 16980613 28386764 9543386
tau protein binding	NAS	28386764
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tau protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
nucleotide binding

Displaying **all 3** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070356	visual impairment and progressive phthisis bulbi	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17169		MGI:1341865	MOUSE07898
Rattus norvegicus	170577		RGD:619883	RATNO36817
Caenorhabditis elegans	179912		WB:WBGene00003916
Danio rerio	334300		ZFIN:ZDB-GENE-030131-6232
Xenopus laevis	399395		Xenbase:XB-GENE-867504
Pan troglodytes	453184	9598_0:0039f7		PANTR09617
Xenopus laevis	495312		Xenbase:XB-GENE-17342379
Bos taurus	534872			BOVIN17074
Canis lupus familiaris	611285			CANLF18250
Macaca mulatta	695234			MACMU42039

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements