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MAS1 proto-oncogene, G protein-coupled receptor

Summary

Gene Symbol

MAS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4142

PubChem

4142

Alliance of Genome Resources

HGNC:6899

Annotation

Keyword

Cell membrane
G-protein coupled receptor
Glycoprotein
Proto-oncogene
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P04201
W8W3P4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	IEA
negative regulation of protein phosphorylation
phospholipase C-activating angiotensin-activated signaling pathway	IMP	16611642
hippocampus development	IEA
response to xenobiotic stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

intracellular signal transduction [inference]

protein kinase C signaling

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

hippocampus development

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to gonadotropin

response to activity

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to gonadotropin

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of small molecule metabolic process [inference]

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of carbohydrate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of small molecule metabolic process [inference]

positive regulation of alcohol biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of response to external stimulus [inference]

regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

angiotensin-activated signaling pathway [inference]

phospholipase C-activating angiotensin-activated signaling pathway

intracellular signal transduction [inference]

protein kinase C signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

positive regulation of DNA replication

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

regulation of cellular biosynthetic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of inositol phosphate biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of inositol phosphate biosynthetic process

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA replication

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA	16611642
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26460884
angiotensin receptor activity	IBA ISS
angiotensin type II receptor activity	TAS	3419518
G protein-coupled receptor activity	IDA	16611642
peptide binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

angiotensin receptor activity

angiotensin type II receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled peptide receptor activity [inference]

angiotensin receptor activity

angiotensin type II receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mas-related G-protein coupled receptor member A

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Mas-related G protein-coupled receptor family

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:1686	glaucoma	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17171		MGI:96918	MOUSE21280
Rattus norvegicus	25153		RGD:3049	RATNO20807
Pan troglodytes	472176	9598_0:001d4a		PANTR39433
Macaca mulatta	703105			MACMU35614
Bos taurus	783010			BOVIN36074
Monodelphis domestica	100027937			MONDO12148
Ornithorhynchus anatinus	100086169			ORNAN15126
Taeniopygia guttata	100219931			TAEGU21364
Pongo abelii	100436788	9601_0:001c6a		PONAB31222
Ailuropoda melanoleuca	100476749			AILME06474

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements