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Annotation

Keyword

3D-structure
Acetylation
Cell cycle
Chromosome
DNA replication
DNA-binding
Disease variant
Helicase
Isopeptide bond
Non-syndromic deafness
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
P49736	Minichromosome maintenance protein 2 homolog Nuclear protein BM28

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
negative regulation of DNA helicase activity	IEA
double-strand break repair via break-induced replication	IBA
DNA replication	TAS	8175912
mitotic DNA replication initiation	IBA
nucleosome assembly	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cell cycle process [inference]

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding [inference]

DNA unwinding involved in DNA replication

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

nucleosome organization [inference]

nucleosome assembly

protein-DNA complex assembly [inference]

nucleosome assembly

developmental process [inference]

anatomical structure development [inference]

cochlea development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interleukin-4 [inference]

cellular response to interleukin-4

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-4

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of DNA duplex unwinding [inference]

negative regulation of DNA helicase activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-templated DNA replication initiation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of DNA duplex unwinding [inference]

negative regulation of DNA helicase activity

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of DNA duplex unwinding [inference]

negative regulation of DNA helicase activity

regulation of chromosome organization [inference]

regulation of DNA duplex unwinding [inference]

negative regulation of DNA duplex unwinding [inference]

negative regulation of DNA helicase activity

regulation of DNA helicase activity [inference]

negative regulation of DNA helicase activity

negative regulation of chromosome organization [inference]

negative regulation of DNA duplex unwinding [inference]

negative regulation of DNA helicase activity

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of DNA duplex unwinding [inference]

negative regulation of DNA helicase activity

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

negative regulation of ATP-dependent activity [inference]

negative regulation of helicase activity [inference]

negative regulation of DNA helicase activity

regulation of helicase activity [inference]

negative regulation of helicase activity [inference]

negative regulation of DNA helicase activity

regulation of DNA helicase activity [inference]

negative regulation of DNA helicase activity

negative regulation of molecular function [inference]

negative regulation of ATP-dependent activity [inference]

negative regulation of helicase activity [inference]

negative regulation of DNA helicase activity

negative regulation of catalytic activity [inference]

negative regulation of helicase activity [inference]

negative regulation of DNA helicase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of helicase activity [inference]

negative regulation of DNA helicase activity

regulation of helicase activity [inference]

negative regulation of helicase activity [inference]

negative regulation of DNA helicase activity

regulation of DNA helicase activity [inference]

negative regulation of DNA helicase activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	HDA	19135898
MCM complex	IBA IDA IPI	17296731 22540012
nucleoplasm	IDA TAS
chromatin	IDA	16899510
nuclear origin of replication recognition complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

origin recognition complex [inference]

nuclear origin of replication recognition complex

protein-DNA complex [inference]

chromatin

DNA replication preinitiation complex [inference]

CMG complex

MCM complex

nuclear protein-containing complex [inference]

nuclear origin of replication recognition complex

DNA replication preinitiation complex [inference]

CMG complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11095689 12740381 15232106 15654075 16189514 16387653 16899510 16902406 17296731 19805216 19819239 19862764 20211142 21044950 21149733 22540012 23764002 24299456 24981860 25036637 25416956 26167883 26496610 27173435 28191891 28514442 31467278 32296183 32769987 33857403 33961781 35271311
DNA binding	TAS	8175912
enzyme binding	IEA
helicase activity
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

DNA helicase activity [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

DNA helicase activity [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA replication licensing factor

Functional Category

K: Transcription
L: Replication, recombination and repair
V: Defense mechanisms
X: Mobilome: prophages, transposons

Displaying **all 8** entries
Gene Ontology
ATP binding
DNA duplex unwinding
DNA unwinding involved in DNA replication
double-strand break repair via break-induced replication
hydrolase activity
metal ion binding
mitotic DNA replication initiation
nucleotide binding

Displaying **all 9** entries
InterPro
DNA replication licensing factor Mcm2
MCM OB domain
MCM domain
MCM, AAA-lid domain
MCM, N-terminal domain
Mini-chromosome maintenance protein
Mini-chromosome maintenance, conserved site
Nucleic acid-binding, OB-fold
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110592	autosomal dominant nonsyndromic deafness 70	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17216		MGI:105380	MOUSE47942
Drosophila melanogaster	40973		FB:FBgn0014861
Caenorhabditis elegans	174841		WB:WBGene00003154
Danio rerio	192338		ZFIN:ZDB-GENE-020419-24	DANRE23580
Rattus norvegicus	312538		RGD:1305577	RATNO31165
Xenopus laevis	380451		Xenbase:XB-GENE-999979
Xenopus tropicalis	448458		Xenbase:XB-GENE-999974
Pan troglodytes	460668	9598_0:001153		PANTR32098
Canis lupus familiaris	484622			CANLF07211
Bos taurus	510120			BOVIN18159

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements