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ADAM metallopeptidase domain 11

Summary

Gene Symbol

ADAM11

Organism

Homo sapiens (human)

External Links

NCBI Gene

4185

PubChem

4185

Alliance of Genome Resources

HGNC:189

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Cleavage on pair of basic residues
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Proteomics identification
Reference proteome
Signal
Synapse
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O75078	Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
B4DKD2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	IBA
behavioral response to formalin induced pain	ISS
multicellular organismal response to stress	ISS
establishment of protein localization	ISS
behavioral response to acetic acid induced pain	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

multicellular organismal process [inference]

behavior [inference]

chemosensory behavior [inference]

behavioral response to chemical pain [inference]

behavioral response to pain [inference]

behavioral response to chemical pain [inference]

multicellular organismal response to stress

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

establishment of localization [inference]

establishment of protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
perikaryon	IEA
collagen-containing extracellular matrix	ISS	22261194
plasma membrane	TAS
presynaptic membrane	IEA
axon	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

perikaryon

Displaying **all 3** entries
GO Term	Evidence Code	PMID
integrin binding	TAS	9693107
metalloendopeptidase activity	IBA
metallopeptidase activity	TAS	9693107

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disintegrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 5** entries
InterPro
ADAM, cysteine-rich domain
Disintegrin domain superfamily
Disintegrin domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11488		MGI:1098667	MOUSE05428
Drosophila melanogaster	32561		FB:FBgn0259110
Caenorhabditis elegans	176706		WB:WBGene00006804
Rattus norvegicus	360638		RGD:1307515	RATNO03494
Xenopus laevis	386622		Xenbase:XB-GENE-966542
Pan troglodytes	454735	9598_0:00489e		PANTR13719
Bos taurus	522375			BOVIN13511
Danio rerio	567145		ZFIN:ZDB-GENE-070808-3	DANRE03978
Canis lupus familiaris	606958			CANLF18628
Equus caballus	100064340			HORSE04827

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements