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malic enzyme 2

Summary

Gene Symbol

ME2

Aliases

NAD-dependent malic enzyme, mitochondrial
malate dehydrogenase (oxaloacetate-decarboxylating)

Organism

Homo sapiens (human)

External Links

NCBI Gene

4200

HGNC

6984

KEGG Gene ID

hsa:4200

PubChem

4200

Alliance of Genome Resources

HGNC:6984

Annotation

Keyword

3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Direct protein sequencing
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P23368	Malic enzyme 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
regulation of NADP metabolic process	IMP	23334421
malate metabolic process	IBA
pyruvate metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of purine nucleotide metabolic process [inference]

regulation of NADP metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
mitochondrial matrix
mitochondrion	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
malate dehydrogenase (decarboxylating) (NAD+) activity	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

malic enzyme activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

oxaloacetate decarboxylase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000082212

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00027

Name

malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]

References

225306

Rhea

H⁺ + oxaloacetate

pyruvate + CO₂

Enzyme

PMID

(S)-malate + NAD⁺

pyruvate + CO₂ + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 21 in total

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DO ID	Disease Name	Source
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0060170	generalized epilepsy with febrile seizures plus	DisGeNET
DOID:10629	microphthalmia	DisGeNET
DOID:11328	schizophreniform disorder	DisGeNET
DOID:1240	leukemia	DisGeNET
DOID:1324	lung cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:1793	pancreatic cancer	DisGeNET
DOID:1826	epilepsy	DisGeNET
DOID:1827	idiopathic generalized epilepsy	DisGeNET DisGeNET

Ortholog

Displaying entries **11 - 20** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	398584	Xenbase:XB-GENE-943061
Xenopus laevis	108718602	Xenbase:XB-GENE-17337095
Xenopus tropicalis	548395	Xenbase:XB-GENE-943055
Chrysemys picta bellii	101936362		CHRPI35805
Crocodylus porosus	109307726		CROPO12189
Pseudonaja textilis	113445681		PSETE02298
Serinus canaria	103824891		SERCA22584
Ornithorhynchus anatinus	100078022		ORNAN17953
Sarcophilus harrisii	100920433		SARHA09405
Callithrix jacchus	100408945		CALJA08543

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Last updated: August 19, 2024