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meprin A subunit alpha

Summary

Gene Symbol

MEP1A

Organism

Homo sapiens (human)

External Links

NCBI Gene

4224

PubChem

4224

Alliance of Genome Resources

HGNC:7015

Annotation

Keyword

3D-structure
Disulfide bond
EGF-like domain
Metal-binding
Metalloprotease
Proteoglycan
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q16819	Endopeptidase-2 N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha PABA peptide hydrolase PPH alpha
B7ZL91	Endopeptidase-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis
signaling receptor ligand precursor processing	IDA	22923609
epidermal growth factor receptor ligand maturation	IDA	22923609

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

hormone metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein metabolic process [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

epidermal growth factor receptor ligand maturation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane
plasma membrane	IDA	22923609
meprin A complex	IDA	9288916
extracellular space	TAS	8262185
extracellular exosome	HDA	11487543

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

meprin A complex

cellular anatomical entity [inference]

extracellular space

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23123160 9288916
zinc ion binding	IEA
metallodipeptidase activity	IDA	22923609
metalloendopeptidase activity	IBA
metallopeptidase activity	IDA	22923609

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallodipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metalloendopeptidase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 3** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M12A
Peptidase, metallopeptidase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17287		MGI:96963	MOUSE21873
Rattus norvegicus	25684		RGD:3080	RATNO42578
Drosophila melanogaster	32856		FB:FBgn0030947
Drosophila melanogaster	34913		FB:FBgn0028950
Drosophila melanogaster	34914		FB:FBgn0028944
Drosophila melanogaster	34915		FB:FBgn0028949
Drosophila melanogaster	34916		FB:FBgn0028948
Drosophila melanogaster	42754		FB:FBgn0039069
Caenorhabditis elegans	181796		WB:WBGene00003525
Caenorhabditis elegans	183207		WB:WBGene00003527

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024