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neither inactivation nor afterpotential E

Summary

Gene Symbol

ninaE

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

42367

PubChem

42367

Alliance of Genome Resources

FB:FBgn0002940

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Retinal protein
Transmembrane helix
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
P06002	Neither inactivation nor afterpotential E protein Outer R1-R6 photoreceptor cells opsin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
phototaxis	IMP	19303299
thermotaxis	IMP	21393546 27705783
photoreceptor cell morphogenesis	IMP	9245510
response to light intensity	IMP	15014127
optomotor response	IMP	19303299

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

rhabdomere development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

visual behavior [inference]

optokinetic behavior [inference]

optomotor response

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

cell morphogenesis involved in neuron differentiation [inference]

photoreceptor cell morphogenesis

locomotion [inference]

taxis [inference]

energy taxis [inference]

phototaxis

thermotaxis

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

thermotaxis

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

optokinetic behavior [inference]

optomotor response

response to UV [inference]

detection of UV

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of developmental process [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

regulation of developmental process [inference]

regulation of retinal cell programmed cell death [inference]

regulation of compound eye retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of developmental process [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

phototransduction

rhodopsin mediated signaling pathway [inference]

phospholipase C-activating rhodopsin mediated signaling pathway

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

regulation of retinal cell programmed cell death [inference]

regulation of compound eye retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of retinal cell programmed cell death [inference]

negative regulation of compound eye retinal cell programmed cell death

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasmic vesicle	IDA	1913822
membrane	IEA
early endosome	IDA	28507272
rhabdomere	IDA	18034157 1838762 1913822 25002678 28507272
perinuclear endoplasmic reticulum	IDA	25002678

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

inaD signaling complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

rhabdomere membrane

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

subrhabdomeral cisterna

cell projection [inference]

plasma membrane bounded cell projection [inference]

rhabdomere

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

perinuclear endoplasmic reticulum

smooth endoplasmic reticulum cisterna [inference]

subrhabdomeral cisterna

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15014127
G protein-coupled photoreceptor activity	IBA IMP NAS	7759511 8338666
G protein-coupled receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled photoreceptor activity

photoreceptor activity [inference]

G protein-coupled photoreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Opsin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cellular response to light stimulus
photoreceptor activity
phototransduction
visual perception

Displaying **all 4** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Opsin
Visual pigments (opsins) retinal binding site

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
perinuclear endoplasmic reticulum	PMID:25002678
membrane	FB:FBrf0231198
cytoplasmic vesicle	PMID:1913822
rhabdomere	PMID:18034157 PMID:1838762 PMID:1913822 PMID:25002678 PMID:28507272
subrhabdomeral cisterna	PMID:1838762
early endosome	PMID:28507272

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0110372	retinitis pigmentosa 4	Alliance of Genome Resources
DOID:10584	retinitis pigmentosa	Alliance of Genome Resources
DOID:5679	retinal disease	Alliance of Genome Resources
DOID:8466	retinal degeneration	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	30044		MGI:1353425
Homo sapiens	94233		HGNC:14449
Rattus norvegicus	192223		RGD:621701
Danio rerio	563080		ZFIN:ZDB-GENE-070705-526
Danio rerio	571624		ZFIN:ZDB-GENE-070111-2
Drosophila pseudoobscura	4802902	7237_1:00027d
Drosophila ananassae	6500137	7217_1:0007ca
Drosophila yakuba	6535739	7245_1:00348a
Drosophila erecta	6553938	7220_1:0004d7
Drosophila grimshawi	6567931	7222_1:001b59