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MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Summary

Gene Symbol

MFNG

Organism

Homo sapiens (human)

External Links

NCBI Gene

4242

GGDB ID

gg132

HGNC

7038

mRNA

NM_002405

map

22q12

Protein

NP_002396

OMIM

602577

KEGG Gene ID

hsa:4242

PubChem

4242

Alliance of Genome Resources

HGNC:7038

Annotation

Keyword

Alternative splicing
Developmental protein
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O00587	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
blastocyst formation	IEA
positive regulation of Notch signaling pathway	IEA
pattern specification process	IEA
marginal zone B cell differentiation	ISS
regulation of Notch signaling pathway	IBA ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

pattern specification process

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

blastocyst formation

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	TAS	9187150
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA IDA	10935626

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg132

Gene Symbol

MFNG

Reactions

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G96881BQ	G26238GL	10935626

Displaying 1 entry
Donor	Acceptor	Product	Reference
UDP-GlcNAc	G96881BQ	G26238GL	10935626

Displaying **all 6** entries
Donor	Acceptor	Reference
UDP-GalNAc	G96881BQ	10935626
UDP-GlcNAc	G71142DF	10935626
UDP-Glc	G96881BQ	10935626
UDP-Gal	G96881BQ	10935626
UDP-GlcNAc	G96881BQ	10935626
UDP-GlcNAc	G65889KE	10935626

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_954541	NM_199110
Mus musculus	NP_032621	NM_008595

KEGG BRITE Database

Orthology

K05948

Name

fringe [EC:2.4.1.222]

References

9187150

Rhea

RHEA:70531

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

RHEA:70511

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.222

PMID

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	40314	FB:FBgn0011591
Danio rerio	493633	ZFIN:ZDB-GENE-041130-1	DANRE22680
Astyanax mexicanus	103035856		ASTMX14529
Ictalurus punctatus	108259517		ICTPU22242
Electrophorus electricus	113589668		ELEEL43491
Salmo salar	106593718		SALSA24719
Salmo trutta	115191205		SALTR49103
Salmo trutta	115191206		SALTR49103
Gadus morhua	115541001		GADMO43764
Oreochromis niloticus	100708834		ORENI61380