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ataxin 3

Summary

Gene Symbol

ATXN3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4287

PubChem

4287

Alliance of Genome Resources

HGNC:7106

Annotation

Keyword

3D-structure
Alternative splicing
Isopeptide bond
Lysosome
Membrane
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Spinocerebellar ataxia
Thiol protease
Transcription regulation
Triplet repeat expansion
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0A0MS38
P54252	Machado-Joseph disease protein 1 Spinocerebellar ataxia type 3 protein
C9JQV6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 21 in total

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GO Term	Evidence Code	PMID
protein K63-linked deubiquitination	IDA	22970133
ubiquitin-dependent protein catabolic process	ISS
intermediate filament cytoskeleton organization	IMP	20637808
negative regulation of TORC1 signaling	IBA IDA	33157014
nervous system development	TAS	9124802

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

protein quality control for misfolded or incompletely synthesized proteins

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

nucleotide-excision repair

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cytosolic proteasome complex

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

nucleotide-excision repair

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to stress [inference]

response to heat [inference]

cellular response to heat

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

nucleotide-excision repair

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to topologically incorrect protein [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to misfolded protein [inference]

cellular response to misfolded protein

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

cellular response to heat

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

response to misfolded protein [inference]

cellular response to misfolded protein

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

nucleotide-excision repair

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to heat

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to misfolded protein

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cytosolic proteasome complex

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cytosolic proteasome complex

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of proteolysis [inference]

positive regulation of proteolysis involved in protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of ERAD pathway

positive regulation of ubiquitin-dependent protein catabolic process

positive regulation of cellular process [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of response to stimulus [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion

positive regulation of cellular process [inference]

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of ERAD pathway [inference]

positive regulation of ERAD pathway

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of ERAD pathway

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA TAS
mitochondrial matrix	ISS
nucleus	IBA IDA	24548080
synapse	IEA
cytosol	IDA TAS	24548080

GO Hierarchy

cellular component

cellular anatomical entity [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

nuclear inclusion body

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

nuclear matrix

cell junction [inference]

synapse

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16525503 16713569 17000876 19153604 20414249 21386698 21625540 22970133 24063750 28445460 30455355 31379806 32814053
cysteine-type deubiquitinase activity	IBA IDA ISS TAS	33157014
K63-linked deubiquitinase activity	IDA	22970133
identical protein binding	IPI	16525503 22129356
K48-linked deubiquitinase activity	IDA	22970133

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

ATPase binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATAXIN-3

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hydrolase activity
proteolysis

Displaying **all 2** entries
InterPro
Josephin domain
Machado-Joseph disease protein

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060892	late onset Parkinson's disease	Alliance of Genome Resources
DOID:1440	Machado-Joseph disease	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 64 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Cavia porcellus	100719182		CAVPO23124
Cricetulus griseus	100754332		CRIGR18893
Pan paniscus	100976906	9597_0:003b8c
Papio anubis	101018946		PAPAN35683
Felis catus	101096738		FELCA14473
Gorilla gorilla gorilla	101136095	9595_0:003d69
Tursiops truncatus	101334012		TURTR09150
Jaculus jaculus	101612995		JACJA00310
Melopsittacus undulatus	101873912		MELUD06776
Chinchilla lanigera	102024385		CHILA10606

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements