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nuclear receptor subfamily 3 group C member 2

Summary

Gene Symbol

NR3C2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4306

PubChem

4306

Alliance of Genome Resources

HGNC:7979

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA-binding
Disease variant
Endoplasmic reticulum
Membrane
Nucleus
Phosphoprotein
Receptor
Reference proteome
Steroid-binding
Transcription regulation
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08235	Nuclear receptor subfamily 3 group C member 2
B0ZBF6	Nuclear receptor subfamily 3 group C member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular steroid hormone receptor signaling pathway	IBA
positive regulation of non-canonical NF-kappaB signal transduction	IMP	30769772
regulation of transcription by RNA polymerase II	IBA
signal transduction	TAS	3037703

GO Hierarchy

biological process

cellular process [inference]

signal transduction

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of non-canonical NF-kappaB signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of non-canonical NF-kappaB signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of cellular process [inference]

signal transduction

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of non-canonical NF-kappaB signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of non-canonical NF-kappaB signal transduction

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
receptor complex	IDA	23382219
endoplasmic reticulum membrane	IEA
nucleoplasm	IDA TAS
chromatin	IBA ISA
nucleus	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

receptor complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11518808
zinc ion binding	IEA
nuclear receptor activity	IBA
nuclear steroid receptor activity	TAS	9662404
steroid binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription factor binding [inference]

general transcription initiation factor binding [inference]

TBP-class protein binding

lipid binding [inference]

steroid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding [inference]

estrogen response element binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding [inference]

estrogen response element binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding [inference]

estrogen response element binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding [inference]

estrogen response element binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding [inference]

estrogen response element binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding [inference]

estrogen response element binding

steroid binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transcription regulator activity [inference]

DNA-binding transcription factor activity

DNA-binding transcription factor activity, RNA polymerase II-specific

nuclear receptor activity

ligand-activated transcription factor activity [inference]

nuclear receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nuclear receptor subfamily 3 group C member 1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
estrogen response element binding
intracellular steroid hormone receptor signaling pathway
metal ion binding
sequence-specific DNA binding
zinc ion binding

Displaying **all 5** entries
InterPro
Nuclear hormone receptor, ligand-binding domain
Nuclear hormone receptor-like domain superfamily
Nuclear hormone receptor
Zinc finger, NHR/GATA-type
Zinc finger, nuclear hormone receptor-type

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0050696	fetal alcohol spectrum disorder	Alliance of Genome Resources
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060855	autosomal dominant pseudohypoaldosteronism type 1	Alliance of Genome Resources
DOID:11612	polycystic ovary syndrome	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:2560	morphine dependence	Alliance of Genome Resources
DOID:4479	pseudohypoaldosteronism	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	25672		RGD:3094	RATNO14413
Mus musculus	110784		MGI:99459	MOUSE57553
Xenopus laevis	399290		Xenbase:XB-GENE-483089
Pan troglodytes	461533	9598_0:0015d7		PANTR34612
Canis lupus familiaris	475461			CANLF04317
Bos taurus	537614			BOVIN09083
Danio rerio	562171		ZFIN:ZDB-GENE-060531-23	DANRE17587
Macaca mulatta	704789			MACMU36249
Taeniopygia guttata	751776			TAEGU23143
Equus caballus	100062570			HORSE28083