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matrix metallopeptidase 2

Summary

Gene Symbol

MMP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4313

PubChem

4313

Alliance of Genome Resources

HGNC:7166

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Autocatalytic cleavage
Calcium
Collagen degradation
Cytoplasm
Direct protein sequencing
Disease variant
Disulfide bond
Extracellular matrix
Glycoprotein
Membrane
Metal-binding
Metalloprotease
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P08253	72 kDa gelatinase Gelatinase A Matrix metalloproteinase-2 TBE-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 45 in total

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GO Term	Evidence Code	PMID
prostate gland epithelium morphogenesis	IEA
peripheral nervous system axon regeneration	IEA
tissue remodeling	IBA
embryo implantation	IEA
cellular response to reactive oxygen species	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

macrophage migration [inference]

macrophage chemotaxis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

collagen catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

collagen metabolic process [inference]

collagen catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell motility [inference]

cell migration

leukocyte migration [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

myeloid leukocyte migration [inference]

macrophage migration [inference]

macrophage chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to fluid shear stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

axon development [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

extracellular structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

external encapsulating structure organization [inference]

extracellular matrix organization

extracellular matrix disassembly

reproductive process [inference]

developmental process involved in reproduction [inference]

embryo implantation

ovulation cycle process [inference]

multi-organism reproductive process [inference]

parturition

multicellular organismal reproductive process [inference]

ovulation [inference]

ovulation from ovarian follicle

multicellular organismal process [inference]

ossification [inference]

direct ossification [inference]

intramembranous ossification

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

multi-multicellular organism process [inference]

parturition

tissue remodeling

developmental process [inference]

developmental process involved in reproduction [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

prostate gland epithelium morphogenesis

face morphogenesis

developmental maturation [inference]

anatomical structure maturation [inference]

blood vessel maturation

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

trabecula formation [inference]

bone trabecula formation

anatomical structure development [inference]

ovarian follicle development

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

macrophage chemotaxis

rhythmic process [inference]

ovulation cycle process [inference]

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to wounding [inference]

response to axon injury [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to fluid shear stress

response to fluid shear stress [inference]

cellular response to fluid shear stress

response to hyperoxia

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

cellular response to UV [inference]

cellular response to UV-A

response to UV-A [inference]

cellular response to UV-A

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to increased oxygen levels [inference]

response to hyperoxia

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

response to endogenous stimulus [inference]

response to hormone [inference]

response to estrogen

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to activity

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to estrogen

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to peptide [inference]

response to amyloid-beta

response to organic cyclic compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

response to lipid [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to retinoic acid

cellular response to lipid [inference]

cellular response to estradiol stimulus

response to cytokine [inference]

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

response to hydrogen peroxide

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to inorganic substance [inference]

response to hydrogen peroxide

response to nicotine

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to peptide [inference]

response to amyloid-beta

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to retinoic acid

response to amino acid [inference]

cellular response to amino acid stimulus

response to peptide [inference]

response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to fluid shear stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-A

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ephrin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of neuron apoptotic process [inference]

positive regulation of neuron apoptotic process [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation [inference]

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of apoptotic signaling pathway [inference]

positive regulation of intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [inference]

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	HDA	23979707 28327460
plasma membrane	IEA
extracellular region	TAS
mitochondrion	IEA
extracellular space	HDA IBA IDA	18492766 20551380 24236012 24784232

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

sarcomere

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12032297 20979576 21441952 25613181 25897080 28106549 28514442 32296183 32814053 33961781
zinc ion binding	IEA
metalloendopeptidase activity	IBA TAS
endopeptidase activity	IDA	23845380
metallopeptidase activity	IDA	24236012 31879982

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

fibronectin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

metallopeptidase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
collagen catabolic process
extracellular matrix organization
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 9** entries
InterPro
Hemopexin-like domain superfamily
Hemopexin-like repeats
Metallopeptidase, catalytic domain superfamily
PGBD-like superfamily
Peptidase M10, metallopeptidase
Peptidase M10A, catalytic domain
Peptidase M10A
Peptidase, metallopeptidase
Peptidoglycan binding-like

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0002116	pterygium	Alliance of Genome Resources
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0060074	ductal carcinoma in situ	Alliance of Genome Resources
DOID:0060224	atrial fibrillation	Alliance of Genome Resources
DOID:0080334	aortic valve disease 2	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0080746	Sweet syndrome	Alliance of Genome Resources
DOID:0080933	immunoglobulin light chain amyloidosis	Alliance of Genome Resources
DOID:0080998	acute necrotizing pancreatitis	Alliance of Genome Resources
DOID:0081292	traumatic brain injury	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17390		MGI:97009	MOUSE59201
Rattus norvegicus	81686		RGD:621316	RATNO14309
Caenorhabditis elegans	179991		WB:WBGene00012364
Caenorhabditis elegans	180351		WB:WBGene00012185
Caenorhabditis elegans	186927		WB:WBGene00010524
Bos taurus	282872			BOVIN10446
Danio rerio	337179		ZFIN:ZDB-GENE-030131-9123	DANRE40883
Xenopus laevis	380389		Xenbase:XB-GENE-482845
Ovis aries	443115			SHEEP05028
Pan troglodytes	454094	9598_0:0040e5		PANTR12377

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements