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N-methylpurine DNA glycosylase

Summary

Gene Symbol

MPG

Aliases

MDG
alkyladenine DNA glycosylase

Organism

Homo sapiens (human)

External Links

NCBI Gene

4350

HGNC

7211

PubChem

4350

Alliance of Genome Resources

HGNC:7211

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
DNA repair
Hydrolase
Mitochondrion nucleoid
Nucleus
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P29372	3-alkyladenine DNA glycosylase 3-methyladenine DNA glycosidase ADPG N-methylpurine-DNA glycosylase
Q1W6H1	3-methyladenine DNA glycosidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
base-excision repair	IBA
DNA dealkylation involved in DNA repair	TAS	1645538
depurination	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

DNA dealkylation [inference]

DNA dealkylation involved in DNA repair

depurination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	IDA
mitochondrial nucleoid	IEA
nucleoplasm	IDA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
DNA-7-methyladenine glycosylase activity	IEA
DNA N-glycosylase activity	TAS
DNA-3-methyladenine glycosylase activity	IEA
DNA-7-methylguanine glycosylase activity	IEA
alkylbase DNA N-glycosylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

alkylbase DNA N-glycosylase activity

DNA-3-methylbase glycosylase activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity

alkylbase DNA N-glycosylase activity

DNA-3-methylbase glycosylase activity [inference]

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000103152

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying entries **11 - 20** of 95 in total

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DO ID	Disease Name	Source
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET
DOID:0110044	Alzheimer's disease 11	DisGeNET
DOID:0110045	Alzheimer's disease 12	DisGeNET
DOID:0110046	Alzheimer's disease 13	DisGeNET
DOID:0110047	Alzheimer's disease 14	DisGeNET
DOID:0110048	Alzheimer's disease 15	DisGeNET
DOID:0110844	xeroderma pigmentosum group C	DisGeNET
DOID:0110892	inflammatory bowel disease 1	DisGeNET
DOID:10652	Alzheimer's disease	DisGeNET

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Latimeria chalumnae	102358841		LATCH17161
Danio rerio	566516	ZFIN:ZDB-GENE-070410-121	DANRE31955
Ictalurus punctatus	108257125		ICTPU18753
Electrophorus electricus	113592113		ELEEL03991
Salmo salar	106601084		SALSA116227
Salmo salar	106607370		SALSA133068
Salmo trutta	115171212		SALTR92623
Salmo trutta	115198932		SALTR24134
Gadus morhua	115560829		GADMO38571
Oreochromis niloticus	100690447		ORENI53298

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: August 19, 2024