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Activin-beta

Summary

Gene Symbol

Actbeta

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

43826

PubChem

43826

Alliance of Genome Resources

FB:FBgn0024913

Annotation

Keyword

Cleavage on pair of basic residues
Developmental protein
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O61643	Activin beta chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
regulation of imaginal disc-derived wing size	IMP	23485686
regulation of synapse structure or activity	IMP	25255438
R8 cell fate specification	IMP	28853393
positive regulation of neuroblast proliferation	IGI	18171686
response to glucose	IEP	28178568

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

photoreceptor cell fate specification [inference]

R8 cell fate specification

developmental process [inference]

anatomical structure development [inference]

mushroom body development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification [inference]

photoreceptor cell fate specification [inference]

R8 cell fate specification

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of carbohydrate catabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of carbohydrate catabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

regulation of developmental growth [inference]

regulation of imaginal disc growth [inference]

positive regulation of imaginal disc growth

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of developmental growth [inference]

regulation of imaginal disc growth [inference]

positive regulation of imaginal disc growth

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental growth [inference]

positive regulation of imaginal disc growth

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

activin receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of biological quality [inference]

regulation of synapse structure or activity

regulation of anatomical structure size [inference]

regulation of imaginal disc-derived wing size

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
growth factor activity	IEA
cytokine activity	IBA
protein binding	IPI	18077144

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inhibin beta A chain

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cytokine activity
growth factor activity

Displaying **all 4** entries
InterPro
Cystine-knot cytokine
Transforming growth factor beta, conserved site
Transforming growth factor-beta, C-terminal
Transforming growth factor-beta-related

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	Alliance of Genome Resources
DOID:0050827	rheumatic heart disease	Alliance of Genome Resources
DOID:11714	gestational diabetes	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:8466	retinal degeneration	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	3624	HGNC:6066
Homo sapiens	3625	HGNC:6067
Homo sapiens	3626	HGNC:6068
Mus musculus	16323	MGI:96570
Mus musculus	16324	MGI:96571
Mus musculus	16325	MGI:105932
Mus musculus	16326	MGI:109269
Rattus norvegicus	25196	RGD:2913
Rattus norvegicus	29200	RGD:62074
Danio rerio	30072	ZFIN:ZDB-GENE-000210-21

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