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prostaglandin-endoperoxide synthase 2

Summary

Gene Symbol

PTGS2

Organism

Canis lupus familiaris (dog)

External Links

NCBI Gene: 442942
KEGG Gene ID: cfa:442942
PubChem: 442942

Annotation

Keyword

Dioxygenase
EGF-like domain
Heme
Microsome
Peroxidase
Prostaglandin biosynthesis
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8P0NFH5	Cyclooxygenase-2 PHS II Prostaglandin H2 synthase 2 Prostaglandin-endoperoxide synthase 2
Q8SPQ9	Cyclooxygenase-2 PHS II Prostaglandin H2 synthase 2 Prostaglandin-endoperoxide synthase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
response to oxidative stress	IEA	22301074
cyclooxygenase pathway	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

cyclooxygenase pathway

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202
neuron projection	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peroxidase activity	IEA	22301074
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	30032202
heme binding	IEA	22301074
prostaglandin-endoperoxide synthase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

prostaglandin-endoperoxide synthase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

binding [inference]

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K11987

Name

prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]

References

Rhea

RHEA:23728

O₂ + AH₂ + (5Z,8Z,11Z,14Z)-eicosatetraenoate

A + H₂O + prostaglandin H₂

Enzyme

1.14.99.1

PMID

Ortholog

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Callorhinchus milii	103179983	CALMI19298
Latimeria chalumnae	102352257	LATCH04028
Danio rerio	559020	DANRE19531
Astyanax mexicanus	103034574	ASTMX03844
Ictalurus punctatus	108257974	ICTPU20699
Electrophorus electricus	113585124	ELEEL35143
Salmo salar	106583970	SALSA85060
Salmo trutta	115158768	SALTR108338
Salmo trutta	115192190	SALTR28375
Gadus morhua	115555681	GADMO06902