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secreted phosphoprotein 1

Summary

Gene Symbol

SPP1

Organism

Ovis aries (sheep)

External Links

NCBI Gene: 443058
PubChem: 443058

Annotation

Keyword

Biomineralization
Cell adhesion
Cytokine
Phosphoprotein
Proteoglycan
Reference proteome
Secreted
Sialic acid
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9XSY9	Bone sialoprotein 1 Secreted phosphoprotein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ossification	IEA	22301074 30032202
osteoblast differentiation	IEA	30032202
cell adhesion	IEA	22301074 30032202
biomineral tissue development
positive regulation of bone resorption	IEA	30032202

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

multicellular organismal process [inference]

ossification

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytokine activity
integrin binding
extracellular matrix binding	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

receptor ligand activity [inference]

cytokine activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

extracellular matrix binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

osteopontin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
extracellular matrix binding
ossification
osteoblast differentiation
positive regulation of bone resorption

Displaying 1 entry
InterPro
Osteopontin

Ortholog

Displaying entries **1 - 10** of 51 in total

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Homo sapiens	6696	HUMAN76508
Mus musculus	20750	MOUSE43572
Rattus norvegicus	25353	RATNO09046
Sus scrofa	397087	PIGXX34459
Pan troglodytes	461366	PANTR34091
Canis lupus familiaris	478471	CANLF13056
Macaca mulatta	704930	MACMU36992
Oryctolagus cuniculus	100008982	RABIT05239
Monodelphis domestica	100016723	MONDO27205
Equus caballus	100053029	HORSE30638