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tollo

Summary

Gene Symbol

Tollo

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

44497

PubChem

44497

Alliance of Genome Resources

FB:FBgn0029114

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Innate immunity
Leucine-rich repeat
NAD
Neurogenesis
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9V477	Toll-like receptor 8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
peripheral nervous system neuron development	IMP	18000549
convergent extension	IGI	25363762
innate immune response
regulation of protein glycosylation	IMP	17264077
axis elongation	IGI	25363762

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

signal transduction

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

peripheral nervous system neuron development

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

convergent extension

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

peripheral nervous system neuron development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

peripheral nervous system neuron development

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

axis elongation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of glycoprotein biosynthetic process [inference]

regulation of protein glycosylation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of glycoprotein biosynthetic process [inference]

regulation of protein glycosylation

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

regulation of protein glycosylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of glycoprotein biosynthetic process [inference]

regulation of protein glycosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

regulation of protein glycosylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein glycosylation

regulation of glycoprotein metabolic process [inference]

regulation of glycoprotein biosynthetic process [inference]

regulation of protein glycosylation

regulation of cellular process [inference]

signal transduction

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of glycoprotein biosynthetic process [inference]

regulation of protein glycosylation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
apical plasma membrane
plasma membrane	IDA	36890234

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
NAD+ nucleotidase, cyclic ADP-ribose generating
receptor ligand activity	IPI	36890234

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

NAD+ nucleosidase activity [inference]

NAD+ nucleotidase, cyclic ADP-ribose generating

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
plasma membrane	PMID:36890234

Ortholog

Displaying entries **1 - 10** of 43 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Caenorhabditis elegans	171635		WB:WBGene00006593
Mus musculus	279572		MGI:3045213
Rattus norvegicus	317227		RGD:1562655
Danio rerio	402884		ZFIN:ZDB-GENE-040220-4
Danio rerio	403135		ZFIN:ZDB-GENE-040220-5
Drosophila pseudoobscura	4812856	7237_1:002b55
Drosophila ananassae	6506332	7217_1:00128b
Drosophila yakuba	6534466	7245_1:002778
Drosophila erecta	6544604	7220_1:001391
Drosophila grimshawi	6570791	7222_1:00227a

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements