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myospheroid

Summary

Gene Symbol

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

44885

PubChem

44885

Alliance of Genome Resources

FB:FBgn0004657

Annotation

Keyword

Behavior
Cell adhesion
Cell membrane
Developmental protein
Disulfide bond
Flight
Glycoprotein
Integrin
Olfaction
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Vision

Proteins

Displaying **all 3** entries
UniProt	Protein Name
X2JE30
P11584	Position-specific antigen beta subunit Protein myospheroid Protein olfactory C
X2JAU0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **26 - 30** of 40 in total

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GO Term	Evidence Code	PMID
axon guidance	IMP	12040052
germ-band extension	IMP	21089076
imaginal disc-derived male genitalia morphogenesis	IMP	20152825
visual perception
central nervous system development	IMP	2492244

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion

cell-matrix adhesion

calcium-dependent cell-matrix adhesion

substrate adhesion-dependent cell spreading

cell adhesion mediated by integrin

cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

hemocyte migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

substrate-dependent cell migration, cell extension

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

substrate-dependent cell migration, cell extension

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

plasma membrane bounded cell projection assembly [inference]

substrate-dependent cell migration, cell extension

supramolecular fiber organization [inference]

actin filament organization

reproductive process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

cellular process involved in reproduction in multicellular organism [inference]

follicle cell of egg chamber migration [inference]

border follicle cell migration

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of smell

sensory perception of light stimulus [inference]

visual perception

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

flight behavior

adult behavior [inference]

adult locomotory behavior [inference]

flight behavior

stem cell population maintenance [inference]

germ-line stem cell population maintenance

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of epithelial integrity, open tracheal system

developmental process [inference]

developmental process involved in reproduction [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

animal organ morphogenesis [inference]

genitalia morphogenesis [inference]

post-embryonic genitalia morphogenesis [inference]

imaginal disc-derived genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

central nervous system morphogenesis

appendage morphogenesis [inference]

imaginal disc-derived appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

post-embryonic appendage morphogenesis [inference]

imaginal disc-derived wing morphogenesis

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium [inference]

dorsal closure

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet [inference]

pericardium morphogenesis

morphogenesis of embryonic epithelium [inference]

dorsal closure

male anatomical structure morphogenesis [inference]

male genitalia morphogenesis [inference]

imaginal disc-derived male genitalia morphogenesis

anatomical structure development [inference]

tube development [inference]

digestive tract development [inference]

midgut development

animal organ development [inference]

ventral cord development

heart development [inference]

larval heart development

muscle organ development

gland development [inference]

salivary gland development

system development [inference]

central nervous system development

muscle structure development [inference]

muscle organ development

maintenance of cell number [inference]

stem cell population maintenance [inference]

germ-line stem cell population maintenance

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

dorsal trunk growth, open tracheal system

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of epithelial integrity, open tracheal system

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of synapse maturation

positive regulation of developmental process [inference]

positive regulation of synapse maturation

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

positive regulation of developmental process [inference]

positive regulation of synapse maturation

regulation of synapse maturation [inference]

positive regulation of synapse maturation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of synapse maturation

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of synapse organization [inference]

regulation of synapse maturation [inference]

positive regulation of synapse maturation

positive regulation of cellular component organization [inference]

positive regulation of synapse maturation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

regulation of stress fiber assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

negative regulation of cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration

regulation of biological quality [inference]

regulation of cell shape

regulation of tube architecture, open tracheal system [inference]

maintenance of epithelial integrity, open tracheal system

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
postsynaptic membrane	IMP	28219985
focal adhesion	IBA IDA	19903692 34496252
lateral plasma membrane	IDA	19035354
apical plasma membrane
cell leading edge	IDA	15596544

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

lateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

cell leading edge

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

costamere

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16569666 28219985
integrin binding	IBA
protein heterodimerization activity	IPI	7972082 9409675
extracellular matrix protein binding	IPI	7924982

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

protein dimerization activity [inference]

protein heterodimerization activity

cell adhesion molecule binding [inference]

integrin binding

extracellular matrix protein binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Integrin beta

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell adhesion mediated by integrin
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 7** entries
InterPro
Integrin beta subunit, VWA domain
Integrin beta subunit, cytoplasmic domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin domain superfamily
von Willebrand factor A-like domain superfamily

Alliance of Genome Resources

Expression

Displaying entries **1 - 10** of 11 in total

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Location	References
focal adhesion	PMID:19903692 PMID:34496252
basal plasma membrane	PMID:19035354 PMID:8898242
plasma membrane	PMID:16569666 PMID:19035354 PMID:19317464 PMID:23410794 PMID:26896675 PMID:7972082
muscle tendon junction	PMID:21347281
membrane	FB:FBrf0231198
cell leading edge	PMID:15596544
costamere	PMID:21347281 PMID:26110760
lateral plasma membrane	PMID:19035354
integrin complex	PMID:7972082
dendrite	PMID:26853303

Disease

Disease Ontology

Displaying entries **31 - 36** of 36 in total

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DO ID	Disease Name	Source
DOID:874	bacterial pneumonia	Alliance of Genome Resources
DOID:8893	psoriasis	Alliance of Genome Resources
DOID:8924	autoimmune thrombocytopenic purpura	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources
DOID:9675	pulmonary emphysema	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Xenopus tropicalis	100486332		Xenbase:XB-GENE-1012435
Xenopus tropicalis	100492659		Xenbase:XB-GENE-988513
Danio rerio	100499533		ZFIN:ZDB-GENE-100812-2
Drosophila suzukii	108019071	28584_0:003049
Drosophila biarmipes	108023951	125945_0:002836
Drosophila rhopaloa	108048540	1041015_1:003043
Drosophila takahashii	108055738	29030_1:0002ec
Drosophila kikkawai	108074247	30033_1:0015c4
Drosophila ficusphila	108097921	30025_1:000752
Drosophila eugracilis	108103448	29029_0:00336c

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements