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cytochrome c oxidase subunit I

Summary

Gene Symbol

COX1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4512

PubChem

4512

Alliance of Genome Resources

HGNC:7419

Annotation

Keyword

3D-structure
Calcium
Copper
Disease variant
Heme
Leber hereditary optic neuropathy
Magnesium
Mitochondrion inner membrane
Non-syndromic deafness
Reference proteome
Respiratory chain
Sodium
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
U5YWV7
P00395	Cytochrome c oxidase polypeptide I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
aerobic respiration	IBA
mitochondrial electron transport, cytochrome c to oxygen	NAS	30030519
electron transport coupled proton transport
response to hypoxia	IEA
cerebellum development	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport [inference]

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

developmental process [inference]

anatomical structure development [inference]

cerebellum development

response to stimulus [inference]

response to stress [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to copper ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport [inference]

energy coupled proton transmembrane transport, against electrochemical gradient [inference]

electron transport coupled proton transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial membrane	IDA	30030519
mitochondrial respiratory chain complex IV
mitochondrial inner membrane	TAS
mitochondrion	HTP	34800366
respiratory chain complex IV	IBA IDA IMP	1651240 19393246 23168492

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex IV

respiratory chain complex [inference]

respiratory chain complex IV

mitochondrial respiratory chain complex IV

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex IV

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex IV

mitochondrial respiratory chain complex IV

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12762840 23260140 26321642 29154948 33961781
metal ion binding	IEA
heme binding	IEA
cytochrome-c oxidase activity	IBA IMP	12140182

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

cytochrome-c oxidase activity

oxidoreductase activity, acting on a heme group of donors [inference]

cytochrome-c oxidase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:3762	cytochrome-c oxidase deficiency disease	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17708	MGI:102504	MOUSE64518
Rattus norvegicus	26195	RGD:621871	RATNO44115
Danio rerio	140539	ZFIN:ZDB-GENE-011205-14	DANRE45623
Drosophila melanogaster	192469	FB:FBgn0013674
Kryptolebias marmoratus	804465		KRYMA29338
Canis lupus familiaris	804478		CANLF19487
Vombatus ursinus	804526		VOMUR32450
Ursus maritimus	804864		URSMA33573
Ictalurus punctatus	804884		ICTPU00324
Esox lucius	806651		ESOLU00483