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5-methyltetrahydrofolate-homocysteine methyltransferase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

4548

PubChem

4548

Alliance of Genome Resources

HGNC:7468

Annotation

Keyword

3D-structure
Alternative splicing
Cobalamin
Cytoplasm
Disease variant
Metal-binding
Methionine biosynthesis
Methyltransferase
Phosphoprotein
Reference proteome
Repeat
S-adenosyl-L-methionine
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q99707	5-methyltetrahydrofolate--homocysteine methyltransferase Cobalamin-dependent methionine synthase Vitamin-B12 dependent methionine synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
homocysteine metabolic process	IBA
cellular response to nitric oxide	ISS
cobalamin metabolic process	IMP TAS	23825108
tetrahydrofolate metabolic process	IBA
response to axon injury	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process [inference]

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

homocysteine metabolic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

methylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process [inference]

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

homocysteine metabolic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

cellular aromatic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process [inference]

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

homocysteine metabolic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process [inference]

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

homocysteine metabolic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

cobalamin metabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process [inference]

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

homocysteine metabolic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process [inference]

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

homocysteine metabolic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process [inference]

methionine biosynthetic process

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

homocysteine metabolic process

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

cellular modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

cellular aromatic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

methionine metabolic process [inference]

methionine biosynthetic process

homocysteine metabolic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

aspartate family amino acid biosynthetic process [inference]

methionine biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

methionine biosynthetic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to nitrogen compound [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration

axon development [inference]

axon regeneration

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration

system development [inference]

nervous system development

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

response to chemical [inference]

response to inorganic substance [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

response to nitric oxide [inference]

cellular response to nitric oxide

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to nitrogen compound [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

response to nitrogen compound [inference]

response to nitric oxide [inference]

cellular response to nitric oxide

cellular response to nitrogen compound [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

response to oxygen-containing compound [inference]

response to nitric oxide [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to nitric oxide

cellular response to nitrogen compound [inference]

cellular response to reactive nitrogen species [inference]

cellular response to nitric oxide

cellular response to oxygen-containing compound [inference]

cellular response to nitric oxide

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IBA IDA TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17288554 23825108 27771510
zinc ion binding	IEA
cobalamin binding	IEA
methionine synthase activity	IBA IDA IMP TAS	16769880 23825108

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

S-methyltransferase activity [inference]

methionine synthase activity

5-methyltetrahydrofolate-dependent methyltransferase activity [inference]

methionine synthase activity

binding [inference]

protein binding

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

homocysteine S-methyltransferase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair

Displaying **all 5** entries
Gene Ontology
metal ion binding
methionine biosynthetic process
methylation
transferase activity
zinc ion binding

Displaying **all 2** entries
InterPro
Homocysteine-binding domain superfamily
Homocysteine-binding domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:0050696	fetal alcohol spectrum disorder	Alliance of Genome Resources
DOID:0050731	vitamin B12 deficiency	Alliance of Genome Resources
DOID:0050733	methylmalonic aciduria and homocystinuria type cblG	Alliance of Genome Resources
DOID:0080016	spina bifida	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:114	heart disease	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2986	IgA glomerulonephritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	81522		RGD:621283	RATNO12105
Caenorhabditis elegans	174681		WB:WBGene00010988
Mus musculus	238505		MGI:894292	MOUSE11795
Bos taurus	280869			BOVIN22326
Danio rerio	378847		ZFIN:ZDB-GENE-031001-5
Sus scrofa	397300			PIGXX07479
Pan troglodytes	457844	9598_0:0008ab		PANTR24002
Canis lupus familiaris	479190			CANLF14524
Macaca mulatta	717582			MACMU21949
Saccharomyces cerevisiae S288C	850664		SGD:S000003985

GlyTouCan

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UniCarb-DR

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Acknowledgements