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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3

Summary

Gene Symbol

ST8SIA3

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 455436
KEGG Gene ID: ptr:455436
PubChem: 455436

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P61644	Alpha-2,8-sialyltransferase 8C Alpha-2,8-sialyltransferase III Ganglioside GD3 synthase ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 Sia-a2,3-Gal-b1,4-Glc-NAc-R:a2,8-sialyltransferase Sialyltransferase 8C Sialyltransferase St8Sia III

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
sialylation
protein glycosylation	IEA	22301074 30032202
oligosaccharide metabolic process	IEA	30032202
N-glycan processing	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

sialylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sialyltransferase activity
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
ganglioside biosynthetic process
glycoprotein metabolic process
identical protein binding
sialylation
sialyltransferase activity
transferase activity

Displaying **all 3** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29
Sialyltransferase

KEGG BRITE Database

Orthology

K06613

Name

alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8C) [EC:2.4.3.-]

References

9826427

Rhea

RHEA:19313

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→8)-N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl derivative + H⁺ + CMP

Enzyme

2.4.3.8

PMID

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mus musculus	20451		MOUSE23570
Rattus norvegicus	25547		RATNO13948
Homo sapiens	51046	9606_0:002ee9	HUMAN38693
Bos taurus	414349		BOVIN19812
Danio rerio	553510		DANRE20472
Macaca mulatta	698407		MACMU17810
Monodelphis domestica	100016450		MONDO17128
Ornithorhynchus anatinus	100079505		ORNAN18147
Gasterosteus aculeatus	100174870		GASAC05112
Taeniopygia guttata	100229524		TAEGU31448

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements