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mucin 2, oligomeric mucus/gel-forming

Summary

Gene Symbol

MUC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

4583

PubChem

4583

Alliance of Genome Resources

HGNC:7512

Annotation

Keyword

3D-structure
Autocatalytic cleavage
Calcium
Copper
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A3S8TMF2
Q02817	Intestinal mucin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mucus secretion	IMP	17058067
detoxification of copper ion	IDA	36206754
maintenance of gastrointestinal epithelium	IMP	17058067
host-mediated regulation of intestinal microbiota composition	ISS

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium

secretion by tissue [inference]

mucus secretion

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

host-mediated regulation of intestinal microbiota composition

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

host-mediated regulation of intestinal microbiota composition

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

host-mediated regulation of intestinal microbiota composition

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

mucus secretion

secretion by tissue [inference]

mucus secretion

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

mucus secretion

detoxification [inference]

detoxification of inorganic compound [inference]

detoxification of copper ion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular matrix	IBA
Golgi lumen	TAS
inner mucus layer	ISS
collagen-containing extracellular matrix	HDA	25037231
outer mucus layer	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

mucus layer [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	19359471 19432394 34237462
cuprous ion binding	IDA	36206754
cupric ion binding	IDA	36206754

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding [inference]

sulfur compound binding [inference]

cupric ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

LOW QUALITY PROTEIN: mucin-2

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Trypsin Inhibitor-like, cysteine rich domain
VWF/SSPO/Zonadhesin-like, cysteine-rich domain
von Willebrand factor, type D domain

Disease

Disease Ontology

Displaying entries **1 - 10** of 19 in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	Alliance of Genome Resources
DOID:0060071	pre-malignant neoplasm	Alliance of Genome Resources
DOID:0060180	colitis	Alliance of Genome Resources
DOID:0080178	mucositis	Alliance of Genome Resources
DOID:11204	allergic conjunctivitis	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1679	cystitis	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying **all 9** entries
Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	17831		MGI:1339364
Rattus norvegicus	24572		RGD:3123
Drosophila melanogaster	39529		FB:FBgn0029167
Pan troglodytes	745783	9598_0:00333e
Danio rerio	100148804		ZFIN:ZDB-GENE-120822-1
Pongo abelii	100441094	9601_0:002e75
Pan paniscus	100969071	9597_0:002f16
Pongo pygmaeus	129007955	9600_0:003021
Gorilla gorilla gorilla	129525430	9595_0:003537

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements