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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

mutY DNA glycosylase

Summary

Gene Symbol

MUTYH

Aliases

MYH

Organism

Homo sapiens (human)

External Links

NCBI Gene

4595

HGNC

7527

PubChem

4595

Alliance of Genome Resources

HGNC:7527

Annotation

Keyword

3D-structure
4Fe-4S
Alternative splicing
DNA repair
Disease variant
Glycosidase
Mitochondrion
Nucleus
Proteomics identification
Reference proteome
Tumor suppressor

Proteins

Displaying **all 6** entries
UniProt	Protein Name
E5KP28
E5KP26
E5KP27
E9PM53
Q9UIF7	MutY homolog
E5KP25

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
depurination	TAS
negative regulation of necroptotic process	IEA
DNA repair	TAS	8682794
mismatch repair	IBA
base-excision repair	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

DNA modification [inference]

depurination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, AP site formation [inference]

depurination

DNA modification [inference]

depurination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

negative regulation of necroptotic process

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of programmed necrotic cell death [inference]

negative regulation of necroptotic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	IDA TAS
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
MutLbeta complex binding	IDA	11801590
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA
MutSbeta complex binding	IDA	11801590
MutSalpha complex binding	IDA	11801590
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity

mismatch base pair DNA N-glycosylase activity [inference]

purine-specific mismatch base pair DNA N-glycosylase activity

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized purine nucleobase lesion DNA N-glycosylase activity [inference]

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

mismatch repair complex binding [inference]

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding [inference]

oxidized DNA binding [inference]

oxidized purine DNA binding

double-stranded DNA binding [inference]

mismatched DNA binding [inference]

adenine/guanine mispair binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

The Human Phenotype Ontology

Displaying entries **41 - 50** of 61 in total

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HPO ID	HPO Term
HP:0010524	Disturbed sensory perception
HP:0010526	Dysgraphia
HP:0010622	Neoplasm of the skeletal system
HP:0010784	Uterine neoplasm
HP:0010786	Urinary tract neoplasm
HP:0012113	Abnormal circulating creatine concentration
HP:0012126	Stomach cancer
HP:0012174	Glioblastoma multiforme
HP:0012378	Fatigue
HP:0100013	Neoplasm of the breast

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:613659	gastric cancer
OMIM:608456	familial adenomatous polyposis 2
ORPHA:440437	familial colorectal cancer type X
ORPHA:247798	familial adenomatous polyposis 2

PubChem Disease

GHR Health Conditions

Familial adenomatous polyposis

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.1

Last updated: February 17, 2025