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myosin binding protein C3

Summary

Gene Symbol

MYBPC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4607

PubChem

4607

Alliance of Genome Resources

HGNC:7551

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Alternative splicing
Cardiomyopathy
Cell adhesion
Disease variant
Disulfide bond
Immunoglobulin domain
Metal-binding
Methylation
Phosphoprotein
Reference proteome
Repeat
Thick filament
Ubl conjugation
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A5YM48	C-protein, cardiac muscle isoform
Q14896	C-protein, cardiac muscle isoform

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
heart morphogenesis	IMP	7493025
regulation of striated muscle contraction	ISS
cell adhesion	IEA
positive regulation of ATP-dependent activity	ISS
regulation of muscle filament sliding	ISS

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

heart morphogenesis

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of muscle filament sliding

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of muscle filament sliding

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of muscle filament sliding

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of muscle filament sliding

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

positive regulation of ATP-dependent activity

positive regulation of molecular function [inference]

positive regulation of ATP-dependent activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
striated muscle myosin thick filament	ISS
striated muscle myosin thick filament	IDA	10024460
C zone	NAS	15166115
sarcomere	IDA	10024460

GO Hierarchy

cellular component

cellular anatomical entity [inference]

myofilament [inference]

striated muscle myosin thick filament

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber [inference]

myofibril [inference]

cardiac myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber [inference]

myofibril [inference]

cardiac myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

myosin filament [inference]

striated muscle myosin thick filament

contractile fiber [inference]

myofibril [inference]

cardiac myofibril

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
ATPase activator activity	ISS
actin binding	IEA
protein binding	IPI	21569246
structural constituent of muscle	IMP	7493025
myosin binding	IDA	10024460

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of muscle

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

myosin binding

myosin heavy chain binding

titin binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

ATPase regulator activity [inference]

ATPase activator activity

molecular function activator activity [inference]

ATPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Myosin-binding protein C

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080326	familial hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:0081158	dilated cardiomyopathy 1MM	Alliance of Genome Resources
DOID:0110310	hypertrophic cardiomyopathy 4	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	4604	FB:FBgn0035410
Drosophila melanogaster	4606	FB:FBgn0035410
Xenopus tropicalis	4607	Xenbase:XB-GENE-479643
Mus musculus	17868		MOUSE32043
Rattus norvegicus	295929	Xenbase:XB-GENE-479643	RATNO26419
Pan troglodytes	451168		PANTR02802
Canis lupus familiaris	483624		CANLF05847
Danio rerio	556489		DANRE41486
Macaca mulatta	712093		MACMU09465
Bos taurus	767614		BOVIN07529

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements