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peptidylglycine alpha-amidating monooxygenase

Summary

Gene Symbol

PAM

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 461974
PubChem: 461974

Annotation

Keyword

Calcium
Copper
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Lyase
Metal-binding
Monooxygenase
Multifunctional enzyme
Reference proteome
Repeat
Signal
Transmembrane helix
Vitamin C
Zinc

Proteins

Displaying **all 8** entries
UniProt	Protein Name
K7C2P8
H2R5G8
A0A2I3S8J5
A0A6D2XUG8
A0A2J8L7U4
A0A2I3SM67
A0A6D2X512
A0A8I3B0D3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
peptide amidation
peptide metabolic process	IEA	22301074
response to zinc ion

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
transport vesicle membrane
extracellular region	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane

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GO Term	Evidence Code	PMID
protein binding	IEA	22301074
zinc ion binding
peptidylamidoglycolate lyase activity
copper ion binding	IEA	22301074
L-ascorbic acid binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [inference]

peptidylglycine monooxygenase activity

lyase activity [inference]

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

peptidylamidoglycolate lyase activity

catalytic activity, acting on a protein [inference]

peptidylamidoglycolate lyase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

Copper type II, ascorbate-dependent monooxygenase, N-terminal

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying entries **1 - 10** of 13 in total

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Gene Ontology
L-ascorbic acid binding
catalytic activity
copper ion binding
lyase activity
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
peptide amidation
peptide metabolic process
peptidylamidoglycolate lyase activity

Displaying **all 10** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
NHL repeat
PHM/PNGase F domain superfamily
Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Six-bladed beta-propeller, TolB-like

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5066	9606_1:00165b		HUMAN80199
Mus musculus	18484			MOUSE30132
Rattus norvegicus	25508			RATNO43121
Bos taurus	280890			BOVIN34034
Danio rerio	570822			DANRE00295
Macaca mulatta	707733			MACMU39189
Monodelphis domestica	100030601			MONDO16536
Ornithorhynchus anatinus	100073355			ORNAN01447
Oryctolagus cuniculus	100352005			RABIT01820
Callithrix jacchus	100396001			CALJA25194

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024