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myosin IE

Summary

Gene Symbol

MYO1E

Organism

Homo sapiens (human)

External Links

NCBI Gene

4643

PubChem

4643

Alliance of Genome Resources

HGNC:7599

Annotation

Keyword

ATP-binding
Actin-binding
Calmodulin-binding
Cell junction
Cytoplasmic vesicle
Cytoskeleton
Disease variant
Lipid-binding
Myosin
Phosphoprotein
Reference proteome
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q12965	Myosin-Ic Unconventional myosin 1E
Q4KMR3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endocytosis	IBA IMP	17257598
podocyte development	ISS
glomerular basement membrane development	ISS
platelet-derived growth factor receptor signaling pathway	IEA
glomerulus development	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

hemopoiesis [inference]

post-embryonic hemopoiesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal filtration [inference]

glomerular filtration

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

hemopoiesis [inference]

post-embryonic hemopoiesis

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

hemopoiesis [inference]

post-embryonic hemopoiesis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

platelet-derived growth factor receptor signaling pathway

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
myosin complex	TAS	11940582
microvillus	IBA
clathrin-coated vesicle
cuticular plate	IEA
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cuticular plate

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17257598 19846667 21458045
microfilament motor activity	IBA
actin filament binding	IBA IDA	11940582
calmodulin binding	IDA	11940582
ATP hydrolysis activity	IDA	11940582

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

heavy chain

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
actin filament organization
cytoskeletal motor activity
nucleotide binding
vesicle transport along actin filament

Displaying **all 3** entries
InterPro
Kinesin motor domain superfamily
Myosin head, motor domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111131	focal segmental glomerulosclerosis 6	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 99 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	25484		RGD:3144	RATNO40500
Mus musculus	71602		MGI:106621	MOUSE63904
Caenorhabditis elegans	172698		WB:WBGene00002035
Xenopus laevis	380131		Xenbase:XB-GENE-5913975
Danio rerio	393609		ZFIN:ZDB-GENE-040426-1347
Pan troglodytes	453479	9598_0:003cbd		PANTR10447
Canis lupus familiaris	478325			CANLF12560
Bos taurus	523485			BOVIN01258
Danio rerio	555285		ZFIN:ZDB-GENE-030131-5127	DANRE40109
Saccharomyces cerevisiae S288C	853729		SGD:S000001612