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NUBP iron-sulfur cluster assembly factor 1, cytosolic

Summary

Gene Symbol

NUBP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4682

PubChem

4682

Alliance of Genome Resources

HGNC:8041

Annotation

Keyword

4Fe-4S
ATP-binding
Acetylation
Alternative splicing
Cilium
Cilium biogenesis/degradation
Cytoskeleton
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P53384	Nucleotide-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
regulation of cell growth	IMP	18573874
intracellular iron ion homeostasis	IMP	18573874
negative regulation of centrosome duplication	IEA
iron-sulfur cluster assembly	IMP	18573874
iron-sulfur cluster assembly	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

iron-sulfur cluster assembly

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell periphery [inference]

protein localization to cell cortex

microtubule organizing center localization [inference]

centrosome localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

metallo-sulfur cluster assembly [inference]

iron-sulfur cluster assembly

cell projection organization

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell periphery [inference]

protein localization to cell cortex

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell periphery [inference]

protein localization to cell cortex

microtubule organizing center localization [inference]

centrosome localization

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cellular component organization [inference]

regulation of cell growth

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

regulation of centrosome cycle [inference]

regulation of centrosome duplication [inference]

negative regulation of centrosome duplication

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of centrosome cycle [inference]

negative regulation of centrosome duplication

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
Golgi apparatus	IDA
centrosome	IDA
centriole	IEA
cytosol	IDA	18573874

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

centriole

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleotide binding	TAS	7926816
protein binding	IPI	18573874 33961781
ATP binding	IEA
ATP hydrolysis activity	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular carrier activity [inference]

metallochaperone activity [inference]

ATP-dependent FeS chaperone activity

ATP-dependent activity [inference]

ATP-dependent FeS chaperone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytosolic Fe-S cluster assembling factor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
ATP binding
ATP-dependent FeS chaperone activity
iron-sulfur cluster assembly
iron-sulfur cluster binding
metal ion binding
nucleotide binding

Displaying **all 4** entries
InterPro
Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
Iron-sulfur cluster carrier protein-like, conserved site
Mrp/NBP35 ATP-binding protein
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	4682	Xenbase:XB-GENE-992726
Mus musculus	26425		MOUSE19099
Pan troglodytes	453912		PANTR11733
Canis lupus familiaris	479850		CANLF16577
Danio rerio	503919		DANRE30478
Bos taurus	507007		BOVIN20268
Macaca mulatta	710499		MACMU26086
Monodelphis domestica	100018076		MONDO28476
Equus caballus	100056639		HORSE06448
Ornithorhynchus anatinus	100087365		ORNAN15405