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tolloid-like 1

Summary

Gene Symbol

tll1

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

474335

PubChem

474335

Alliance of Genome Resources

ZFIN:ZDB-GENE-041020-1

Annotation

Keyword

Calcium
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O57460	Mini fin protein
B3DJN6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
endothelial cell development	IMP	10375503
proteolysis	IDA IEA	16518392 9395394
embryonic hemopoiesis	IMP	9395394
dorsal/ventral pattern formation	IBA IGI IMP	11969259 16518392 16530746 16824737 20886103
embryonic caudal fin morphogenesis	IMP	10375503 9395394

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

determination of ventral identity

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

fin morphogenesis [inference]

medial fin morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

caudal fin morphogenesis [inference]

embryonic caudal fin morphogenesis

embryonic appendage morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

post-anal tail morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic medial fin morphogenesis [inference]

embryonic caudal fin morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

anatomical structure development [inference]

blood vessel development

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development

hemopoiesis [inference]

embryonic hemopoiesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	NAS	10375503
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16518392
zinc ion binding	IEA ISS	9395394
hydrolase activity	IEA
metal ion binding	IEA
metalloendopeptidase activity	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tolloid

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 3** entries
InterPro
CUB domain
Peptidase M12A
Spermadhesin, CUB domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110111	atrial heart septal defect 6	Alliance of Genome Resources
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **244** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7092	HGNC:11843	HUMAN78036
Mus musculus	21892	MGI:106923	MOUSE58678
Drosophila melanogaster	42944	FB:FBgn0004885
Drosophila melanogaster	42945	FB:FBgn0003719
Rattus norvegicus	290694	RGD:1306120
Canis lupus familiaris	482674		CANLF04382
Xenopus tropicalis	493401	Xenbase:XB-GENE-479941
Bos taurus	616468		BOVIN09017
Rattus norvegicus	678743		RATNO11203
Macaca mulatta	705831		MACMU37209