neuraminidase 1

Summary
Gene Symbol
  • NEU1
Aliases
  • sialidase-1
Organism
Homo sapiens (human)
External Links
NCBI Gene
4758
HGNC
7758
KEGG Gene ID
hsa:4758
PubChem
4758
Alliance of Genome Resources
Annotation
Keyword
  • Carbohydrate metabolism
  • Cell membrane
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Disease variant
  • Glycoprotein
  • Glycosidase
  • Lipid degradation
  • Lysosome
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Proteins
Displaying all 2 entries
UniProt Protein Name
Q5JQI0
  • Lysosomal sialidase
  • N-acetyl-alpha-neuraminidase 1
Q99519
  • Acetylneuraminyl hydrolase
  • G9 sialidase
  • Lysosomal sialidase
  • N-acetyl-alpha-neuraminidase 1
Gene Ontology (GO)
Displaying all 2 entries
GO Term Evidence Code PMID
oligosaccharide catabolic process
ganglioside catabolic process
GO Hierarchy
Displaying entries 1 - 5 of 11 in total
GO Term Evidence Code PMID
cell junction
intracellular membrane-bounded organelle
extracellular region
cytoplasm
plasma membrane
Human Protein Atlas
ENSG00000204386

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K01186
Name
sialidase-1 [EC:3.2.1.18]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R06147
Disease
Disease Ontology
Displaying entries 21 - 30 of 189 in total
DO ID Disease Name Source
DOID:0110038 Alzheimer's disease 6
DOID:0110039 Alzheimer's disease 7
DOID:0110041 Alzheimer's disease 8
DOID:0110043 Alzheimer's disease 10
DOID:0110044 Alzheimer's disease 11
DOID:0110045 Alzheimer's disease 12
DOID:0110046 Alzheimer's disease 13
DOID:0110047 Alzheimer's disease 14
DOID:0110048 Alzheimer's disease 15
DOID:0110892 inflammatory bowel disease 1
The Human Phenotype Ontology
Displaying entries 31 - 40 of 94 in total
HPO ID HPO Term
HP:0001009 Telangiectasia
HP:0001249 Intellectual disability
HP:0001250 Seizure
HP:0001251 Ataxia
HP:0001252 Hypotonia
HP:0001257 Spasticity
HP:0001263 Global developmental delay
HP:0001270 Motor delay
HP:0001288 Gait disturbance
HP:0001290 Generalized hypotonia
Displaying all 4 entries
Disease ID Disease Name
ORPHA:812
  • sialidosis type 1
  • sialidosis type 2
ORPHA:93399
  • juvenile sialidosis type 2
OMIM:256550
  • sialidosis type 2
ORPHA:93400
  • congenital sialidosis type 2
PubChem Disease
GHR Health Conditions
MedGen Diseases
OMIM Phenotypes
KEGG Diseases
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001729
Gene Name
sialidase 1 (lysosomal sialidase)
Ortholog
Displaying entries 71 - 73 of 73 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
103724424 NANGA24254
103271293 CARSF12569
115602811 STRHB06082

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: August 19, 2024