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cellular communication network factor 3

Summary

Gene Symbol

CCN3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4856

PubChem

4856

Alliance of Genome Resources

HGNC:7885

Annotation

Keyword

Cytoplasm
Direct protein sequencing
Disulfide bond
Gap junction
Glycoprotein
Growth factor
Palmitate
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P48745	Cellular communication network factor 3 Insulin-like growth factor-binding protein 9 Nephro blastoma-overexpressed gene protein homolog Protein NOV homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
bone regeneration	ISS
negative regulation of cell growth	IMP	15181016
cell adhesion mediated by integrin	IDA	12695522 15611078
negative regulation of non-canonical NF-kappaB signal transduction	IMP	21063504
positive regulation of Notch signaling pathway	IDA	12050162 20139355

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell adhesion mediated by integrin

cell-cell adhesion [inference]

epithelial cell-cell adhesion [inference]

endothelial cell-cell adhesion

signal transduction

cell population proliferation [inference]

muscle cell proliferation [inference]

smooth muscle cell proliferation

epithelial cell proliferation [inference]

type B pancreatic cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration [inference]

endothelial cell chemotaxis

fibroblast migration

muscle cell migration [inference]

smooth muscle cell migration

cell chemotaxis

endothelial cell chemotaxis

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

regeneration [inference]

tissue regeneration [inference]

bone regeneration

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

bone regeneration

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

endothelial cell chemotaxis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of non-canonical NF-kappaB signal transduction [inference]

negative regulation of non-canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of developmental process [inference]

positive regulation of cell differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of ossification

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of chondrocyte proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of cell growth

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of sensory perception of pain

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of non-canonical NF-kappaB signal transduction [inference]

negative regulation of non-canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

positive regulation of cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

negative regulation of myotube differentiation

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

negative regulation of SMAD protein signal transduction

regulation of non-canonical NF-kappaB signal transduction [inference]

negative regulation of non-canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of chondrocyte proliferation

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

positive regulation of cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation [inference]

negative regulation of myotube differentiation

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of chondrocyte proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of SMAD protein signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of cell growth

negative regulation of cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of myotube differentiation

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of monocyte chemotaxis

negative regulation of mononuclear cell migration [inference]

negative regulation of monocyte chemotaxis

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

positive regulation of ossification

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of sensory perception of pain

regulation of sensory perception [inference]

regulation of sensory perception of pain [inference]

negative regulation of sensory perception of pain

positive regulation of multicellular organismal process [inference]

positive regulation of ossification

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of sensory perception of pain

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular matrix	IBA
collagen-containing extracellular matrix	IEA
neuronal cell body	IEA
intracellular membrane-bounded organelle	IDA
gap junction	IMP ISS	15181016

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

gap junction

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15181016 15213231 21653829 32296183 9927660
integrin binding	IBA IPI	12695522 15611078
heparin binding	IBA
Notch binding	IPI	12050162
hormone activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

WNT1-inducible-signaling pathway 1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
heparin binding
integrin binding

Displaying **all 8** entries
InterPro
CCN, TSP1 domain
Cystine knot, C-terminal
Glycoprotein hormone subunit beta
Growth factor receptor cysteine-rich domain superfamily
Insulin-like growth factor-binding protein, IGFBP
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat
VWFC domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18133		MGI:109185	MOUSE16254
Drosophila melanogaster	39972		FB:FBgn0052183
Rattus norvegicus	81526		RGD:621553	RATNO39185
Xenopus laevis	373662		Xenbase:XB-GENE-1013047
Canis lupus familiaris	475083			CANLF03175
Bos taurus	505727			BOVIN06022
Macaca mulatta	702196			MACMU43246
Pan troglodytes	737818	9598_0:002408		PANTR43173
Monodelphis domestica	100031859			MONDO18122
Equus caballus	100057055			HORSE42580

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

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Acknowledgements