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NPHS1 adhesion molecule, nephrin

Summary

Gene Symbol

NPHS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4868

PubChem

4868

Alliance of Genome Resources

HGNC:7908

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Myogenesis
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O60500	Renal glomerulus-specific cell adhesion receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cell-cell adhesion	IBA
slit diaphragm assembly	ISS TAS	9660941
podocyte development	IEP	17464107
JNK cascade	IEA
myoblast fusion	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

cell adhesion [inference]

cell-cell adhesion

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

filtration diaphragm assembly [inference]

slit diaphragm assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

glomerular basement membrane development

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion [inference]

myoblast fusion

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

glomerular basement membrane development

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

cellular developmental process [inference]

cell development [inference]

epithelial cell development [inference]

glomerular epithelial cell development [inference]

podocyte development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to synapse

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

JNK cascade

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament polymerization

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament polymerization

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

positive regulation of actin filament polymerization

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
focal adhesion	IEA
plasma membrane	IBA IDA ISS TAS	17464107
cell projection	IEA
slit diaphragm	ISS
cell-cell junction	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

filtration diaphragm [inference]

slit diaphragm

cell-substrate junction [inference]

focal adhesion

cell projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16525419 21858180 22662192
myosin binding	IPI	21402783
cell adhesion molecule binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

myosin binding

cell adhesion molecule binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cell adhesion molecule

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
CD80-like, immunoglobulin C2-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0080390	nephrotic syndrome type 1	Alliance of Genome Resources
DOID:1074	kidney failure	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:557	kidney disease	Alliance of Genome Resources
DOID:576	proteinuria	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	44097		FB:FBgn0024189
Mus musculus	54631		MGI:1859637	MOUSE55048
Rattus norvegicus	64563		RGD:620460
Caenorhabditis elegans	181561		WB:WBGene00007750
Pan troglodytes	468841	9598_0:004f73		PANTR18042
Canis lupus familiaris	484571			CANLF01180
Bos taurus	519706			BOVIN10918
Danio rerio	692352		ZFIN:ZDB-GENE-051102-1	DANRE09476
Macaca mulatta	718929			MACMU18069
Xenopus laevis	734213		Xenbase:XB-GENE-487815

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Last updated: December 9, 2024