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natriuretic peptide receptor 3

Summary

Gene Symbol

NPR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4883

PubChem

4883

Alliance of Genome Resources

HGNC:7945

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Chloride
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P17342	Atrial natriuretic peptide clearance receptor Atrial natriuretic peptide receptor type C
A8K4A5
Q60I31

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
negative regulation of cold-induced thermogenesis	ISS	22307324
blood vessel remodeling	IEA
regulation of osteoblast proliferation	ISS
angiogenesis	IEA
response to ischemia	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

osteoclast proliferation

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

positive regulation of urine volume

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

system development [inference]

skeletal system development

response to stimulus [inference]

response to stress [inference]

response to ischemia

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

regulation of osteoblast proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume [inference]

positive regulation of urine volume

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

positive regulation of nitric-oxide synthase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein-containing complex	IDA	16870210
plasma membrane	IC	1660465
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
peptide binding	IPI	16870210
peptide hormone binding	IBA IPI ISS	1660465
protein homodimerization activity	IDA	16870210

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding

peptide hormone binding

hormone binding

peptide hormone binding

ion binding [inference]

anion binding [inference]

chloride ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080001	bone disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements