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natriuretic peptide receptor 3

Summary

Gene Symbol

NPR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

4883

PubChem

4883

Alliance of Genome Resources

HGNC:7945

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Chloride
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P17342	Atrial natriuretic peptide clearance receptor Atrial natriuretic peptide receptor type C
A8K4A5
Q60I31

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
response to ischemia	IEA
negative regulation of cold-induced thermogenesis	ISS	22307324
blood vessel remodeling	IEA
positive regulation of urine volume	ISS
regulation of blood pressure	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

cell population proliferation [inference]

leukocyte proliferation [inference]

osteoclast proliferation

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

positive regulation of urine volume

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

system development [inference]

skeletal system development

response to stimulus [inference]

response to stress [inference]

response to ischemia

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

regulation of osteoblast proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume [inference]

positive regulation of urine volume

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

positive regulation of nitric-oxide synthase activity

positive regulation of oxidoreductase activity [inference]

positive regulation of monooxygenase activity [inference]

positive regulation of nitric-oxide synthase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein-containing complex	IDA	16870210
plasma membrane	IC	1660465
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
chloride ion binding	IDA	16870210
protein homodimerization activity	IDA	16870210
peptide binding	IPI	16870210

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding

peptide hormone binding

hormone binding

peptide hormone binding

ion binding [inference]

anion binding [inference]

chloride ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

natriuretic peptide receptor 3

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
natriuretic peptide receptor activity
peptide hormone binding

Displaying **all 3** entries
InterPro
Adenylyl cyclase class-4/guanylyl cyclase
Periplasmic binding protein-like I
Receptor, ligand binding region

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080001	bone disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Oryzias latipes	100049289			ORYLA18077
Equus caballus	100068418			HORSE20439
Ornithorhynchus anatinus	100077225			ORNAN18290
Taeniopygia guttata	100226141			TAEGU31014
Oryctolagus cuniculus	100354361			RABIT01891
Pongo abelii	100451062	9601_0:001692		PONAB30016
Xenopus tropicalis	100495974		Xenbase:XB-GENE-1012470
Nomascus leucogenys	100583106			NOMLE31993
Sus scrofa	100626363			PIGXX10438
Loxodonta africana	100656855			LOXAF16634

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements