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neuropeptide Y receptor Y5

Summary

Gene Symbol

NPY5R

Organism

Homo sapiens (human)

External Links

NCBI Gene

4889

PubChem

4889

Alliance of Genome Resources

HGNC:7958

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15761	NPY-Y5 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of acute inflammatory response	IEA
negative regulation of acute inflammatory response to antigenic stimulus	IEA
outflow tract morphogenesis	IMP	19593212
cardiac left ventricle morphogenesis	IMP	19593212
G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic signaling via neuropeptide

signal transduction [inference]

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

reproductive process [inference]

ovulation cycle process [inference]

generation of ovulation cycle rhythm

multicellular organismal process [inference]

behavior [inference]

feeding behavior [inference]

eating behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

outflow tract morphogenesis

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac left ventricle morphogenesis

rhythmic process [inference]

ovulation cycle process [inference]

generation of ovulation cycle rhythm

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic signaling via neuropeptide

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amine transport [inference]

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of amine transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of glutamate secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of acute inflammatory response

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of immune response [inference]

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of immune response [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of acute inflammatory response

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

regulation of acute inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response [inference]

negative regulation of acute inflammatory response [inference]

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of inflammatory response to antigenic stimulus [inference]

negative regulation of acute inflammatory response to antigenic stimulus

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, GABAergic

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
neuron projection	IBA
presynapse	IEA
GABA-ergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

GABA-ergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

presynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptide YY receptor activity	IBA
pancreatic polypeptide receptor activity	IBA
neuropeptide Y receptor activity	TAS	8824284
neuropeptide binding	IBA

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

neuropeptide Y receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

neuropeptide Y receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
positive regulation of flagellated sperm motility
tachykinin receptor activity
tachykinin receptor signaling pathway

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Neurokinin receptor

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3146	lipid metabolism disorder	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	2834	WB:WBGene00008278
Xenopus tropicalis	4889	Xenbase:XB-GENE-960863
Drosophila melanogaster	18166	FB:FBgn0037408
Mus musculus	18168	Xenbase:XB-GENE-960863	MOUSE58754
Drosophila melanogaster	18169	FB:FBgn0037408
Drosophila melanogaster	19065	FB:FBgn0037408
Rattus norvegicus	25340	Xenbase:XB-GENE-960863	RATNO11271
Drosophila melanogaster	29471	FB:FBgn0037408
Drosophila melanogaster	182921	FB:FBgn0037408
Caenorhabditis elegans	226278	WB:WBGene00018067

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Acknowledgements