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NRAS proto-oncogene, GTPase

Summary

Gene Symbol

NRAS

Aliases

N-ras

Organism

Homo sapiens (human)

External Links

NCBI Gene

4893

HGNC

7989

PubChem

4893

Alliance of Genome Resources

HGNC:7989

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Disease variant
GTP-binding
Glycoprotein
Golgi apparatus
Hydrolase
Isopeptide bond
Methylation
Palmitate
Phosphoprotein
Prenylation
Proto-oncogene
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5U091	Transforming protein N-Ras
P01111	Transforming protein N-Ras

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
MAPK cascade	TAS
positive regulation of endothelial cell proliferation	IMP	23619365
Ras protein signal transduction	IBA IDA	30712867
myoblast differentiation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
Golgi apparatus	IDA	21968647
endoplasmic reticulum membrane	TAS
plasma membrane	IBA TAS
tertiary granule membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

tertiary granule membrane

bounding membrane of organelle [inference]

Golgi membrane

secretory granule membrane [inference]

tertiary granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	18641128 20080631 21478863 28514442 30194290 31980649 32296183 32707033 32814053 33961781 34591642
GTPase activity	IBA IDA TAS	30712867
protein-containing complex binding	IDA	23209302
GDP binding	IBA
G protein activity	IEA