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aconitase 1

Summary

Gene Symbol

ACO1

Aliases

IREBP
IRP1
aconitate hydratase, cytoplasmic
cytosplasmic aconitase
soluble aconitase

Organism

Homo sapiens (human)

External Links

NCBI Gene

HGNC

117

KEGG Gene ID

hsa:48

PubChem

Alliance of Genome Resources

HGNC:117

Annotation

Keyword

3D-structure
4Fe-4S
Cytoplasm
Direct protein sequencing
Lyase
Phosphoprotein
RNA-binding
Reference proteome
Tricarboxylic acid cycle

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P21399	Citrate hydro-lyase Ferritin repressor protein Iron regulatory protein 1 Iron-responsive element-binding protein 1
V9HWB7	Citrate hydro-lyase Iron-responsive element-binding protein 1
Q9HBB2	Citrate hydro-lyase Iron-responsive element-binding protein 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
response to iron(II) ion	IDA	8041788
tricarboxylic acid cycle	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

citrate metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

primary metabolic process [inference]

tricarboxylic acid cycle

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

citrate metabolic process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption

post-embryonic development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to iron ion [inference]

response to iron(II) ion

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	16144863
cytosol	IBA IDA TAS	1281544 16527810
cytoplasm	IMP NAS	1281544 1738601
Golgi apparatus	IDA	16144863
mitochondrion	IBA IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
4 iron, 4 sulfur cluster binding	IBA IDA IMP	1281544 16407072
3 iron, 4 sulfur cluster binding	IBA IMP	1281544
aconitate hydratase activity	IBA IDA IMP	1281544 1946430 8041788
metal ion binding	IEA
iron-responsive element binding	IBA IDA IMP	1281544 23891004 8041788

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

aconitate hydratase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding [inference]

iron-responsive element binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000122729

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:10336

citrate

D-threo-isocitrate

Enzyme

4.2.1.3

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:2355	anemia	DisGeNET
DOID:2361	macrocytic anemia	DisGeNET
DOID:2834	acquired polycythemia	DisGeNET DisGeNET
DOID:2838	stress polycythemia	DisGeNET DisGeNET
DOID:2839	erythropoietin polycythemia	DisGeNET DisGeNET
DOID:3312	bipolar disorder	DisGeNET
DOID:3571	liver cancer	DisGeNET DisGeNET
DOID:381	arthropathy	DisGeNET
DOID:3953	adrenal gland cancer	DisGeNET
DOID:4398	pustulosis of palm and sole	DisGeNET

Ortholog

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Species	Gene ID	Orthologous MAtrix
Macaca nemestrina	105485636	MACNE34712
Papio anubis	100998477	PAPAN07895
Mandrillus leucophaeus	105539629	MANLE17457
Gorilla gorilla gorilla	101132086	GORGO42881
Pan paniscus	100967413	PANPA39361
Pan troglodytes	465034	PANTR43776
Pongo abelii	100173767	PONAB36410
Canis lupus familiaris	481576	CANLF02231
Ursus americanus	123781036	URSAM16041
Ailuropoda melanoleuca	100469198	AILME03466

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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External Links

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Acknowledgements