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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
discoidin domain receptor tyrosine kinase 2
Summary
- Gene Symbol
-
- DDR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Cell membrane
- Disease variant
- Disulfide bond
- Dwarfism
- Glycoprotein
- Osteogenesis
- Phosphoprotein
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Proteins
| UniProt | Protein Name |
|---|---|
| Q16832 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of fibroblast proliferation | ||
| regulation of extracellular matrix disassembly | ||
| positive regulation of DNA-binding transcription factor activity | ||
| positive regulation of vascular associated smooth muscle cell migration | ||
| positive regulation of collagen biosynthetic process |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of cell population proliferation [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell cycle [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| focal adhesion | ||
| apical plasma membrane | ||
| receptor complex | ||
| plasma membrane | ||
| actin cytoskeleton |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein tyrosine kinase collagen receptor activity | ||
| transmembrane receptor protein tyrosine kinase activity | ||
| collagen binding | ||
| ATP binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Discoidin domain-containing receptor
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| collagen binding |
| positive regulation of neuron projection development |
| protein tyrosine kinase collagen receptor activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0112196 | spondylometaepiphyseal dysplasia, short limb-hand type | |
| DOID:10534 | stomach cancer | |
| DOID:14018 | alcoholic liver cirrhosis | |
| DOID:3500 | gallbladder adenocarcinoma | |
| DOID:3907 | lung squamous cell carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:5520 | head and neck squamous cell carcinoma | |
| DOID:5627 | adenosquamous gallbladder carcinoma | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18214 | MGI:1345277 | MOUSE29892 | ||
| 180622 | WB:WBGene00017381 | |||
| 457467 | 9598_0:00064c | PANTR22868 | ||
| 478987 | CANLF14388 | |||
| 533523 | BOVIN25487 | |||
| 556380 | ZFIN:ZDB-GENE-090316-2 | DANRE37908 | ||
| 559428 | ZFIN:ZDB-GENE-060503-361 | |||
| 685781 | RGD:619855 | RATNO07161 | ||
| 720124 | MACMU23650 | |||
| 779954 | Xenbase:XB-GENE-5884186 |
