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nuclear mitotic apparatus protein 1

Summary

Gene Symbol

NUMA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4926

PubChem

4926

Alliance of Genome Resources

HGNC:8059

JoGo

NUMA1

TogoVar

NUMA1

Annotation

Keyword

3D-structure
ADP-ribosylation
Acetylation
Alternative splicing
Cell membrane
Chromosome
Chromosome partition
Coiled coil
Cytoplasm
Cytoskeleton
Glycoprotein
Isopeptide bond
Lipid-binding
Lipoprotein
Microtubule
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q14980	Nuclear matrix protein-22 Nuclear mitotic apparatus protein SP-H antigen
Q3SYK8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 25 in total

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GO Term	Evidence Code	PMID
positive regulation of intracellular transport	IMP	27462074
positive regulation of keratinocyte differentiation	ISS
cell division	IEA
meiotic cell cycle	IEA
positive regulation of hair follicle development	ISS

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

astral microtubule organization

spindle assembly [inference]

anastral spindle assembly

cytoplasmic microtubule organization [inference]

astral microtubule organization

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cell cycle [inference]

meiotic cell cycle

cell cycle process [inference]

spindle organization [inference]

astral microtubule organization

spindle assembly [inference]

anastral spindle assembly

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation

spindle organization [inference]

astral microtubule organization

spindle assembly [inference]

anastral spindle assembly

cytoplasmic microtubule organization [inference]

astral microtubule organization

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

anastral spindle assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly [inference]

anastral spindle assembly

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

astral microtubule organization

reproductive process [inference]

meiotic cell cycle

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport

positive regulation of transport [inference]

positive regulation of intracellular transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport

regulation of protein localization [inference]

regulation of protein localization to spindle pole body [inference]

positive regulation of protein localization to spindle pole body

positive regulation of protein localization [inference]

positive regulation of protein localization to spindle pole body

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell cortex [inference]

positive regulation of protein localization to cell cortex

regulation of metaphase plate congression

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of intracellular transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of chromosome organization [inference]

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of protein localization [inference]

positive regulation of protein localization to spindle pole body

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transport [inference]

positive regulation of intracellular transport

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of hair follicle development

positive regulation of multicellular organismal process [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of epidermis development [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of hair follicle development

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of hair follicle development [inference]

positive regulation of hair follicle development

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of microtubule-based process [inference]

regulation of spindle elongation [inference]

regulation of mitotic spindle elongation [inference]

positive regulation of mitotic spindle elongation

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of spindle assembly [inference]

positive regulation of spindle assembly

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of intracellular transport

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of chromosome organization [inference]

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

positive regulation of protein localization [inference]

positive regulation of protein localization to spindle pole body

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of chromosome organization [inference]

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

positive regulation of chromosome organization [inference]

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

regulation of cytoskeleton organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of spindle assembly

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of spindle assembly [inference]

positive regulation of spindle assembly

regulation of organelle assembly [inference]

regulation of spindle assembly [inference]

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

regulation of protein polymerization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of microtubule polymerization or depolymerization [inference]

positive regulation of microtubule polymerization

positive regulation of spindle assembly

positive regulation of organelle assembly [inference]

positive regulation of spindle assembly

positive regulation of chromosome organization [inference]

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

positive regulation of protein-containing complex assembly [inference]

positive regulation of protein polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule polymerization [inference]

positive regulation of microtubule polymerization

positive regulation of supramolecular fiber organization [inference]

positive regulation of microtubule polymerization

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of spindle elongation [inference]

regulation of mitotic spindle elongation [inference]

positive regulation of mitotic spindle elongation

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

positive regulation of chromosome segregation

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

regulation of chromosome separation [inference]

positive regulation of chromosome separation

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

regulation of spindle organization [inference]

regulation of mitotic spindle organization

regulation of spindle assembly [inference]

positive regulation of spindle assembly

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of chromosome segregation

positive regulation of mitotic sister chromatid segregation [inference]

positive regulation of mitotic spindle elongation

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport

regulation of protein localization [inference]

regulation of protein localization to spindle pole body [inference]

positive regulation of protein localization to spindle pole body

positive regulation of protein localization [inference]

positive regulation of protein localization to spindle pole body

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell cortex [inference]

positive regulation of protein localization to cell cortex

regulation of multicellular organismal process [inference]

regulation of hair cycle [inference]

regulation of hair follicle development [inference]

positive regulation of hair follicle development

positive regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

positive regulation of epithelial cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of epidermal cell differentiation [inference]

positive regulation of epidermal cell differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of keratinocyte differentiation [inference]

positive regulation of keratinocyte differentiation

regulation of hair follicle development [inference]

positive regulation of hair follicle development

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
spindle pole	IDA	14718566 18331714 23921553
spindle pole	IBA
nucleus	IDA	1541636 23921553 27462074
nucleoplasm	TAS
nucleoplasm	IDA	10811826

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

spindle pole

mitotic spindle pole

nucleoplasm

cytoplasm [inference]

cell cortex

cell cortex region

lateral cell cortex

cytoplasmic region [inference]

cell cortex region

lateral cell cortex

microtubule organizing center [inference]

centrosome

spindle pole centrosome

cytosol

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

spindle

mitotic spindle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

spindle

mitotic spindle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

spindle midzone [inference]

mitotic spindle midzone

microtubule bundle

cytoplasmic microtubule bundle

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

spindle microtubule

astral microtubule [inference]

mitotic spindle astral microtubule

cytoplasmic microtubule [inference]

astral microtubule [inference]

mitotic spindle astral microtubule

cortical microtubule

microtubule end [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
structural molecule activity	TAS	1541630
protein binding	IPI	11590136 11781568 12080061 12445386 15537540 16076287 17172455 20109190 21044950 21816348 22153077 22327364 23665171 23870127 24996901 25416956 26195665 27462074 30021884 33961781 35271311
microtubule binding	IDA	11956313 12445386 27462074
microtubule binding	IBA
tubulin binding	IDA	11956313