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erythropoietin

Summary

Gene Symbol

EPO

Organism

Felis catus (domestic cat)

External Links

NCBI Gene: 493801
PubChem: 493801

Annotation

Keyword

Disulfide bond
Erythrocyte maturation
Glycoprotein
Hormone
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P33708

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
positive regulation of cell population proliferation
erythrocyte differentiation
positive regulation of Ras protein signal transduction
erythrocyte maturation
erythropoietin-mediated signaling pathway

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

erythropoietin-mediated signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cell maturation [inference]

erythrocyte maturation

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

erythrocyte maturation

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

cell maturation [inference]

erythrocyte maturation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

erythropoietin-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of intracellular signal transduction [inference]

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074 30032202
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
erythropoietin receptor binding	IEA	22301074 30032202
protein kinase activator activity
hormone activity	IEA	22301074
cytokine activity	IEA	30032202

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

erythropoietin receptor binding

receptor ligand activity [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Erythropoietin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
cell population proliferation
cytokine activity
hormone activity
positive regulation of ERK1 and ERK2 cascade
positive regulation of hematopoietic stem cell proliferation
signaling receptor binding
thrombopoietin-mediated signaling pathway

Displaying **all 2** entries
InterPro
Erythropoietin/thrombopoietin
Four-helical cytokine-like, core

Ortholog

Displaying entries **11 - 20** of 99 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Oryctolagus cuniculus	100008786		RABIT11321
Equus caballus	100033849		HORSE06627
Callithrix jacchus	100394313		CALJA25853
Pongo abelii	100459890		PONAB33766
Ailuropoda melanoleuca	100483785	9646_0:002b9b	AILME04474
Nomascus leucogenys	100607433		NOMLE12557
Oreochromis niloticus	100707671		ORENI49383
Cavia porcellus	100712648		CAVPO13468
Cricetulus griseus	100753960		CRIGR20872
Sarcophilus harrisii	100924490		SARHA15256