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ATPase H+/K+ transporting subunit beta

Summary

Gene Symbol

ATP4B

Organism

Homo sapiens (human)

External Links

NCBI Gene

496

PubChem

496

Alliance of Genome Resources

HGNC:820

Annotation

Keyword

Cell adhesion
Cell membrane
Disulfide bond
Glycoprotein
Hydrogen ion transport
Potassium transport
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P51164	Gastric H(+)/K(+) ATPase subunit beta Proton pump beta chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
intracellular sodium ion homeostasis	IBA
cell adhesion	IEA
intracellular potassium ion homeostasis	IBA
response to lipopolysaccharide	IEA
sodium ion export across plasma membrane	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH [inference]

pH reduction

intracellular monoatomic cation homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

potassium ion homeostasis [inference]

intracellular potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport [inference]

sodium ion export across plasma membrane

potassium ion transmembrane transport

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

proton transmembrane transport

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export across plasma membrane [inference]

sodium ion export across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

export from cell [inference]

export across plasma membrane [inference]

sodium ion export across plasma membrane

biological regulation [inference]

regulation of pH [inference]

pH reduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
potassium:proton exchanging ATPase complex	ISO
sodium:potassium-exchanging ATPase complex	IBA
apical plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

cation-transporting ATPase complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ATPase activator activity	IBA
protein binding	IPI	25416956 32296183
P-type potassium:proton transporter activity	TAS	1656976
heterocyclic compound binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding

molecular function regulator activity [inference]

ATPase regulator activity [inference]

ATPase activator activity

molecular function activator activity [inference]

ATPase activator activity

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

P-type transmembrane transporter activity [inference]

P-type ion transporter activity [inference]

P-type proton-exporting transporter activity [inference]

P-type potassium:proton transporter activity

P-type potassium transmembrane transporter activity [inference]

P-type potassium:proton transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium/potassium-transporting ATPase subunit beta

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATPase activator activity
intracellular sodium ion homeostasis

Displaying **all 2** entries
InterPro
Sodium/potassium-transporting ATPase subunit beta superfamily
Sodium/potassium-transporting ATPase subunit beta

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0040090	autoimmune gastritis	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:8929	atrophic gastritis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	481	FB:FBgn0015777
Drosophila melanogaster	482	FB:FBgn0015777
Drosophila melanogaster	483	FB:FBgn0015777
Xenopus tropicalis	496	Xenbase:XB-GENE-944891
Drosophila melanogaster	11931	FB:FBgn0015777
Drosophila melanogaster	11932	FB:FBgn0015777
Drosophila melanogaster	11933	FB:FBgn0015777
Mus musculus	11945	Xenbase:XB-GENE-944891	MOUSE58015
Rattus norvegicus	24217	Xenbase:XB-GENE-944891	RATNO10763
Drosophila melanogaster	25390	FB:FBgn0015777